Phenotypes associated with this allele

• Allele Symbol: tga
• Allele Name: transposition of the great arteries
• Allele ID: MGI:3522332
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	tga/tga	C57BL/6J-tga	MGI:3522708

Genotype
MGI:3522708

hm1

• Allelic Composition: tga/tga
• Genetic Background: C57BL/6J-tga

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

right aortic arch ( J:94456 )

• some mutants have right sided aortic arch

abnormal cardiovascular development ( J:94456 )

abnormal heart morphology ( J:94456 )

• ectopic pigmentation is seen in the heart and chest cavity

abnormal coronary artery morphology ( J:94456 )

• the left coronary artery sinus ballons into the ventricular septum

transposition of great arteries ( J:94456 )

• the two parallel outflows are positioned in an anterior/posterior arrangement, with the pulmonary trunk behind the aorta

• the aorta connected to the RV, whereas the pulmonary outflow emerged from the LV

right atrial isomerism ( J:94456 )

• the right and left superior vena cava insert symmetrically into the roof of the right and left atria

complete atrioventricular septal defect ( J:94456 )

• a direct connection between the atrial and ventricular chambers is seen

abnormal heart ventricle morphology ( J:94456 )

• in some cases the morphology of the ventricles is inverted resulting in 'corrected' transposition of the great vessels

semilunar valve regurgitation ( J:94456 )

• outflow regurgitation is seen

growth/size/body

right atrial isomerism ( J:94456 )

• the right and left superior vena cava insert symmetrically into the roof of the right and left atria

immune system

thymus hypoplasia ( J:94456 )

hematopoietic system

thymus hypoplasia ( J:94456 )

endocrine/exocrine glands

thymus hypoplasia ( J:94456 )