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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr5tm1Sush
targeted mutation 1, Kouji Matsushima
MGI:3522335
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccr5tm1Sush/Ccr5tm1Sush B6.129P2-Ccr5tm1Sush MGI:3527433


Genotype
MGI:3527433
hm1
Allelic
Composition		 Ccr5tm1Sush/Ccr5tm1Sush
Genetic
Background		 B6.129P2-Ccr5tm1Sush
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr5tm1Sush mutation (0 available); any Ccr5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:94937 )
• attenuated chemotactic activity of blood mononuclear cells toward the Ccr5 specific chemokine Ccl4 but not Cxcr3
decreased T cell proliferation ( J:94937 )
• splenic CD8+ T cell proliferative response to wild-type peyer's patch CD11c+ dendritic cells was decreased compared to controls

hematopoietic system
abnormal leukocyte physiology ( J:94937 )
• attenuated chemotactic activity of blood mononuclear cells toward the Ccr5 specific chemokine Ccl4 but not Cxcr3
decreased T cell proliferation ( J:94937 )
• splenic CD8+ T cell proliferative response to wild-type peyer's patch CD11c+ dendritic cells was decreased compared to controls

cellular
decreased T cell proliferation ( J:94937 )
• splenic CD8+ T cell proliferative response to wild-type peyer's patch CD11c+ dendritic cells was decreased compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory