All Phenotypes Adam10<tm1Psa> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam10^tm1Psa/Adam10^tm1Psa	either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	MGI:3522637
cx2	Adam10^tm1Psa/Adam10⁺ Hr^hr/Hr^hr	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/Skh	MGI:6163722
cx3	Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl	MGI:6163720

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94943 )

• no viable embryos obtained after E9.5

cardiovascular system

absent intersomitic vessels ( J:94943 )

• absence of smaller segmental vessel branches between somites

failure of vascular branching ( J:94943 )

• absence of smaller segmental vessel branches between somites

abnormal vitelline vasculature morphology ( J:94943 )

• enlarged extraembryonic blood vessels filled with large numbers of erythrocytes in the yolk sac at E9.5

delayed heart development ( J:94943 )

• severely retarded development of the heart, with morphology corresponding at E9.5 to an E7.5-E8 stage embryo

distended pericardium ( J:94943 )

• enlarged pericardial sacs that occasionally expanded to extreme sizes at E9.5

embryo

abnormal vitelline vasculature morphology ( J:94943 )

• enlarged extraembryonic blood vessels filled with large numbers of erythrocytes in the yolk sac at E9.5

small first pharyngeal arch ( J:94943 )

• reduced first branchial arch

decreased embryo size ( J:94943 )

• reach about 2/3 of the size of wild-type, with the body region distal to the forelimb buds most growth retarded

abnormal paraxial mesoderm morphology ( J:94943 )

• caudal most somite was followed by a protruding bulge of paraxial mesoderm, corresponding to fused somites

abnormal neural tube morphology ( J:94943 )

• fusing neural tubes had irregularly shaped lateral neuroepithelial walls

abnormal somite development ( J:94943 )

• only the rostral four or five pairs of somites appeared normal although they were irregular in size and less well delineated

• caudal most somite was followed by a protruding bulge of paraxial mesoderm, corresponding to fused somites

abnormal umbilical cord morphology ( J:94943 )

• had extracorporal mesenchymal swellings at the insertion of the umbilical cord

abnormal visceral yolk sac morphology ( J:94943 )

• yolk sacs had enlarged extraembryonic blood vessels filled with large numbers of embryonic erythrocytes and their progenitors

growth/size/body

decreased embryo size ( J:94943 )

• reach about 2/3 of the size of wild-type, with the body region distal to the forelimb buds most growth retarded

nervous system

abnormal neural tube morphology ( J:94943 )

• fusing neural tubes had irregularly shaped lateral neuroepithelial walls

abnormal forebrain development ( J:94943 )

• foreshortened forebrain anlage at E9.5

abnormal pontine flexure morphology ( J:94943 )

• had an abnormal hindbrain flexure at E9.5

craniofacial

small first pharyngeal arch ( J:94943 )

• reduced first branchial arch

Allelic Composition	Adam10^tm1Psa/Adam10⁺ Hr^hr/Hr^hr
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/Skh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^tm1Psa mutation (0 available); any Adam10 mutation (38 available)
Hr^hr mutation (18 available); any Hr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

hairless ( J:262499 )

abnormal skin pigmentation ( J:262499 )

• light brown, freckle-like spots or macules with a striated appearance at 5 months of age

pigmentation

abnormal skin pigmentation ( J:262499 )

• light brown, freckle-like spots or macules with a striated appearance at 5 months of age

Allelic Composition	Adam10^Pied/Adam10^tm1Psa Hr^hr/Hr^hr
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^Pied mutation (0 available); any Adam10 mutation (38 available)
Adam10^tm1Psa mutation (0 available); any Adam10 mutation (38 available)
Hr^hr mutation (18 available); any Hr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small pharyngeal arch ( J:262499 )

• at E9.5

caudal body truncation ( J:262499 )

• at E9.5

decreased embryo size ( J:262499 )

• at E9.5

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

abnormal somite border morphology ( J:262499 )

• not delineated at E9.5

cardiovascular system

abnormal heart looping ( J:262499 )

• linear at E9.5

enlarged pericardium ( J:262499 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:262499 )

• irregularly shaped at E9.5

telencephalon hypoplasia ( J:262499 )

• at E9.5

growth/size/body

decreased embryo size ( J:262499 )

• at E9.5

craniofacial

small pharyngeal arch ( J:262499 )

• at E9.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24