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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb32tm1Iho
targeted mutation 1, I-Cheng Ho
MGI:3522354
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb32tm1Iho/Zbtb32tm1Iho involves: BALB/c MGI:3522633
hm2
 		Zbtb32tm1Iho/Zbtb32tm1Iho involves: C57BL/6 MGI:3522634


Genotype
MGI:3522633
hm1
Allelic
Composition		 Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb32tm1Iho mutation (0 available); any Zbtb32 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:94944 )
• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3
• however susceptibility to experimental autoimmune encephalomyelitis (EAE) is similar to wild-type
abnormal cytokine secretion ( J:94944 )
• stimulated Th cells produce more IL-2 and slightly more IL-4 and dendritic cells produce 50% more IL-12p40

hematopoietic system
increased T cell proliferation ( J:94944 )
• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3
• however susceptibility to experimental autoimmune encephalomyelitis (EAE) is similar to wild-type

cellular
increased T cell proliferation ( J:94944 )
• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3
• however susceptibility to experimental autoimmune encephalomyelitis (EAE) is similar to wild-type




Genotype
MGI:3522634
hm2
Allelic
Composition		 Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb32tm1Iho mutation (0 available); any Zbtb32 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:94944 )
• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3

hematopoietic system
increased T cell proliferation ( J:94944 )
• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3

cellular
increased T cell proliferation ( J:94944 )
• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory