Phenotypes associated with this allele

• Allele Symbol: Nkx6-2^tm1Gow
• Allele Name: targeted mutation 1, Alexander Gow
• Allele ID: MGI:3522433
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx6-2^tm1Gow/Nkx6-2^tm1Gow	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:3522609

Genotype
MGI:3522609

hm1

• Allelic Composition: Nkx6-2^tm1Gow/Nkx6-2^tm1Gow
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:94807 )

• at 6 weeks of age (but not at 3 weeks) exhibited impaired motor coordination in rotarod test that persisted into adulthood

vision/eye

abnormal optic nerve morphology ( J:94807 )

• abnormal myelination of axons in optic nerves at 7 months of age with an increase in cytoplasmic processes that underlie the internodal myelin sheath

• more than 11% of myelinated axons exhibited disorganized paranodes that extended for large distances along the axon and were non-symmetrical

• increased paranodal width at 4 and 8 months of age but not at 3 weeks

• increased paranodal length at 8 months of age but not at 3 weeks or 4 months<

nervous system

abnormal optic nerve morphology ( J:94807 )

• abnormal myelination of axons in optic nerves at 7 months of age with an increase in cytoplasmic processes that underlie the internodal myelin sheath

• more than 11% of myelinated axons exhibited disorganized paranodes that extended for large distances along the axon and were non-symmetrical

• increased paranodal width at 4 and 8 months of age but not at 3 weeks

• increased paranodal length at 8 months of age but not at 3 weeks or 4 months<

axon degeneration ( J:94807 )

• axonal degeneration in 7 month-old optic nerves

abnormal myelination ( J:94807 )

• 7 month old optic nerves showed redundant sheaths around axons, thin myelin, unmyelinated axons, and myelin flaps

• 27% of axons were unmyelinated in optic nerve of mutants

abnormal nerve conduction ( J:94807 )

• slowed conduction velocity in auditory brainstem (longer peak V latencies) at P28 and 4 months of age