Phenotypes associated with this allele

• Allele Symbol: Myh9^tm1Maco
• Allele Name: targeted mutation 1, Mary Anne Conti
• Allele ID: MGI:3522434
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh9^tm1Maco/Myh9^tm1Maco	involves: 129X1/SvJ	MGI:3522571

Genotype
MGI:3522571

hm1

• Allelic Composition: Myh9^tm1Maco/Myh9^tm1Maco
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:94940 , J:163702 )

• no viable homozygous embryos are found after E7.5 (J:94940)

• die at E6.5 (J:163702)

embryo

abnormal germ layer development ( J:94940 , J:163702 )

• the organization of the cell layers is disrupted (J:94940)

• lack identifiable cell layers at E6.5 (J:163702)

failure to gastrulate ( J:163702 )

abnormal visceral endoderm morphology ( J:94940 , J:163702 )

• the visceral endoderm is disarrayed and the cells retain a cuboidal shape (J:94940)

• disorganized at E6.5 (J:163702)

• cell-cell borders lack cadherin 1 (J:163702)