All Phenotypes Cdh2<tm1Glr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdh2^tm1Glr/Cdh2^{Gt(OST49160)Lex} A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:3580161
cn2	Cdh2^tm1Glr/Cdh2^tm1Glr Olig2^tm1(cre)Tmj/Olig2⁺	involves: 129S6/SvEvTac	MGI:5305444
cn3	Cdh2^tm1Glr/Cdh2^tm1Glr Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:5607288
cn4	Cdh2^tm1Glr/Cdh2^tm1Hyn A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:3580162

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:98828 )

• mutants die about 2 months after tamoxifen treatment

cardiovascular system

abnormal cardiovascular system morphology ( J:98828 )

abnormal myocardial fiber morphology ( J:98828 )

• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen

• after tamoxifen treatment intercalated disc structures and intercellular space are absent

• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines

abnormal intercalated disk morphology ( J:98828 )

• after tamoxifen treatment intercalated disc structures are absent

dilated heart atrium ( J:98828 )

• modest dilation of the atria after tamoxifen treatment

abnormal heart shape ( J:98828 )

• after tamoxifen treatment hearts appear elongated and flacid

dilated heart left ventricle ( J:98828 )

• modest dilation of the ventricles after tamoxifen treatment

dilated heart right ventricle ( J:98828 )

• modest dilation of the ventricles after tamoxifen treatment

abnormal cardiovascular system physiology ( J:98828 )

decreased cardiac output ( J:98828 )

decreased heart left ventricle muscle contractility ( J:98828 )

• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased

decreased heart rate ( J:98828 )

• about 5 weeks after tamoxifen treatment, mutant heart rate is significantly reduced

increased heart rate ( J:98828 )

• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death

irregular heartbeat ( J:98828 )

• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death

abnormal impulse conducting system conduction ( J:98828 )

• tachyarrhythmia is initiated by premature ventricular depolarization

muscle

abnormal myocardial fiber morphology ( J:98828 )

• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen

• after tamoxifen treatment intercalated disc structures and intercellular space are absent

• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines

abnormal intercalated disk morphology ( J:98828 )

• after tamoxifen treatment intercalated disc structures are absent

decreased heart left ventricle muscle contractility ( J:98828 )

• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased

Allelic Composition	Cdh2^tm1Glr/Cdh2^tm1Glr Olig2^tm1(cre)Tmj/Olig2⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh2^tm1Glr mutation (1 available); any Cdh2 mutation (51 available)
Olig2^tm1(cre)Tmj mutation (0 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:178688 )

• mice die between E15.5 and P0

lethality throughout fetal growth and development, incomplete penetrance ( J:178688 )

• mice die between E15.5 and P0

nervous system

abnormal neuronal migration ( J:178688 )

• migration and settling of preganglionic neurons in the intermediate spinal cord is defective compared to in control mice

abnormal spinal cord morphology ( J:178688 )

• migration and settling of preganglionic neurons in the intermediate spinal cord is defective compared to in control mice

abnormal spinal cord motor column morphology ( J:178688 )

• mice exhibit a 2-fold increase in mixing of medial and lateral lumbar motor column compared with control mice

cellular

abnormal neuronal migration ( J:178688 )

• migration and settling of preganglionic neurons in the intermediate spinal cord is defective compared to in control mice

Allelic Composition	Cdh2^tm1Glr/Cdh2^tm1Glr Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh2^tm1Glr mutation (1 available); any Cdh2 mutation (51 available)
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal radial glial cell morphology ( J:215584 )

• adherens junctions between radial glial cells are disrupted

abnormal cortical ventricular zone morphology ( J:215584 )

• localization of adherens junction proteins is perturbed in the ventricular zone of the developing dorsal telencephalon at E13.5

abnormal cerebral cortex morphology ( J:215584 )

• laminar structure of the cortex is disrupted

abnormal neocortex morphology ( J:215584 )

• Pax6+ radial glial cells and Tbr2+ progenitor cells and Tuj1+ neurons are distributed throughout the entire thickness of the neocortex and the distribution of cells is not homogenous, and numerous rosette-like structures are detected

thickened cerebral cortex ( J:215584 )

• cortex is severely hyperplastic by P13 and vastly increased in size

abnormal nervous system tract morphology ( J:215584 )

• massive disorganization of axonal tracts

increased neuronal precursor cell number ( J:215584 )

• massive increases in progenitor cell numbers and in their proliferation at E13.5

ectopic neuron ( J:215584 )

• massive heterotopia forms below a thin band of cells near the meninges

cellular

abnormal radial glial cell morphology ( J:215584 )

• adherens junctions between radial glial cells are disrupted

Allelic Composition	Cdh2^tm1Glr/Cdh2^tm1Hyn A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (39 available)
Cdh2^tm1Glr mutation (1 available); any Cdh2 mutation (51 available)
Cdh2^tm1Hyn mutation (1 available); any Cdh2 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:98828 )

• mutants die about 2 months after tamoxifen treatment

cardiovascular system

abnormal cardiovascular system morphology ( J:98828 )

abnormal myocardial fiber morphology ( J:98828 )

• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen

• after tamoxifen treatment intercalated disc structures and intercellular space are absent

• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines

abnormal intercalated disk morphology ( J:98828 )

• after tamoxifen treatment intercalated disc structures are absent

dilated heart atrium ( J:98828 )

• modest dilation of the atria after tamoxifen treatment

abnormal heart shape ( J:98828 )

• after tamoxifen treatment hearts appear elongated and flacid

dilated heart left ventricle ( J:98828 )

• modest dilation of the ventricles after tamoxifen treatment

dilated heart right ventricle ( J:98828 )

• modest dilation of the ventricles after tamoxifen treatment

abnormal cardiovascular system physiology ( J:98828 )

decreased cardiac output ( J:98828 )

decreased heart left ventricle muscle contractility ( J:98828 )

• eft ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased

decreased heart rate ( J:98828 )

• about 5 weeks after tamoxifen treatment, mutant heart rate is significantly reduced

increased heart rate ( J:98828 )

• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death

irregular heartbeat ( J:98828 )

• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death

abnormal impulse conducting system conduction ( J:98828 )

• tachyarrhythmia is initiated by premature ventricular depolarization

muscle

abnormal myocardial fiber morphology ( J:98828 )

• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen

• after tamoxifen treatment intercalated disc structures and intercellular space are absent

• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines

abnormal intercalated disk morphology ( J:98828 )

• after tamoxifen treatment intercalated disc structures are absent

decreased heart left ventricle muscle contractility ( J:98828 )

• eft ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased

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