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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dctn1tm1Cai
targeted mutation 1, Huaibin Cai
MGI:3522484
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dctn1tm1Cai/Dctn1tm1Cai involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3769514
ht2
 		Dctn1tm1Cai/Dctn1+ involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3769515
cx3
 		Dctn1tm1Cai/Dctn1+
Tg(SOD1*G93A)1Gur/0 		involves: 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:3769517


Genotype
MGI:3769514
hm1
Allelic
Composition		 Dctn1tm1Cai/Dctn1tm1Cai
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dctn1tm1Cai mutation (0 available); any Dctn1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth arrest ( J:129269 )
• at E9.5 mice are arrested in development and resemble E8.0 embryos
abnormal neural tube morphology ( J:129269 )
• at E9.5, the neural tube is only partially formed

nervous system
abnormal neural tube morphology ( J:129269 )
• at E9.5, the neural tube is only partially formed

cellular
increased apoptosis ( J:129269 )
• the number of cells undergoing apoptosis is increased compared to in wild-type mice




Genotype
MGI:3769515
ht2
Allelic
Composition		 Dctn1tm1Cai/Dctn1+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dctn1tm1Cai mutation (0 available); any Dctn1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
motor neuron degeneration ( J:129269 )
• 12.98+/-0.22 compared to 15.10+/-0.57 in wild-type mice
abnormal neuromuscular synapse morphology ( J:129269 )
• neurofilament and synaptophysin accumulate at neuromuscular junctions unlike in wild-type mice

behavior/neurological
short stride length ( J:129269 )
• at 16 months, 47.98+/-0.85 mm compared to 57.33+/-1.01 mm for wild-type mice




Genotype
MGI:3769517
cx3
Allelic
Composition		 Dctn1tm1Cai/Dctn1+
Tg(SOD1*G93A)1Gur/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dctn1tm1Cai mutation (0 available); any Dctn1 mutation (65 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
paralysis ( J:129269 )
• mice develop paralysis at the same rate as Tg(SOD1*G93A)1Gur mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory