Phenotypes associated with this allele

• Allele Symbol: Tg(RBP3-TAg)#Ove
• Allele Name: transgene insertion, Paul A Overbeek
• Allele ID: MGI:3522638
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(RBP3-TAg)#Ove/0	involves: C57BL/6 * FVB/N	MGI:2665147

Genotype
MGI:2665147

tg1

• Allelic Composition: Tg(RBP3-TAg)#Ove/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:59267 )

• retinal and brain tumors develop during embryonic and early postnatal stages

• tumors are poorly differentiated with a variable degree of anaplasia

• Homer Wright rosettes are observed in both the retinal and brain tumors

increased retina tumor incidence ( J:59267 )

• varying incidence of retinal tumors

• most retinal tumors are poorly differentiated, although some are more differentiated and disclose peculiar rosettes composed of a single layer of cuboidal cells centered around a small capillary lined by a single layer of flat endothelial cells

increased brain tumor incidence ( J:59267 )

• varying incidence of brain tumors

• cerebral tumors involve mostly the diencephalon but also extend to the midbrain and fourth ventricle

vision/eye

increased retina tumor incidence ( J:59267 )

• varying incidence of retinal tumors

• most retinal tumors are poorly differentiated, although some are more differentiated and disclose peculiar rosettes composed of a single layer of cuboidal cells centered around a small capillary lined by a single layer of flat endothelial cells

retina detachment ( J:59267 )

• ocular tumors lead to total retinal detachment

nervous system

increased brain tumor incidence ( J:59267 )

• varying incidence of brain tumors

• cerebral tumors involve mostly the diencephalon but also extend to the midbrain and fourth ventricle