Phenotypes associated with this allele

• Allele Symbol: Gnl3⁺
• Allele Name: wild type
• Allele ID: MGI:3524892
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gnl3^tm1Rylt/Gnl3^+	involves: 129X1/SvJ * C57BL/6	MGI:3700779
ht2	Gnl3^Gt(W223E05)Wrst/Gnl3^+	Not Specified	MGI:3702080

Genotype
MGI:3700779

ht1

• Allelic Composition: Gnl3^tm1Rylt/Gnl3⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:117592 )

• in passages 3 - 5, the number of cells in G2/M increases in heterozygous MEFs but not in wild-type MEFs

increased fibroblast apoptosis ( J:117592 )

• in MEFs in passages 4 and 5

decreased fibroblast proliferation ( J:117592 )

• after passage 3, population doubling level is decreased in heterozygous MEFs compared to wild-type cells

early cellular replicative senescence ( J:117592 )

• from passages 5 through 7, the number of senescent cells is higher in heterozygous compared to wild-type MEFs

Genotype
MGI:3702080

ht2

• Allelic Composition: Gnl3^{Gt(W223E05)Wrst}/Gnl3⁺
• Genetic Background: Not Specified

cellular

decreased cell proliferation ( J:118144 )

• late, but not early, passages of MEFs show a slight but reproducible decrease in cell proliferation