Phenotypes associated with this allele

• Allele Symbol: Tg(Gh-Gal)4599Vron
• Allele Name: transgene insertion 4599, M E Vrontakis
• Allele ID: MGI:3524994
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Gh-Gal)4599Vron/Tg(Gh-Gal)4599Vron	B6.Cg-Tg(Gh-Gal)4599Vron	MGI:5572814
tg2	Tg(Gh-Gal)4599Vron/?	involves: C57BL/6 * CD-1 * SJL	MGI:5572833

Genotype
MGI:5572814

tg1

• Allelic Composition: Tg(Gh-Gal)4599Vron/Tg(Gh-Gal)4599Vron
• Genetic Background: B6.Cg-Tg(Gh-Gal)4599Vron

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased epididymal fat pad weight ( J:210298 )

♂

increased abdominal fat pad weight ( J:210298 )

♂ • visceral fat pad is increased

growth/size/body

increased body size ( J:210298 )

♂ • waist circumference is increased

increased body weight ( J:210298 )

♂ • beginning at 2 months of age, body weight is increased as compared to controls

♂ • body weight is increased to 35.6% of controls by 9 months, however food intake is not increased

increased body length ( J:210298 )

♂

enlarged liver ( J:210298 )

♂

homeostasis/metabolism

increased circulating insulin level ( J:210298 )

♂ • fasting and non-fasting serum insulin is increased as compared to controls

decreased oxygen consumption ( J:210298 )

♂ • decrease in VO2 and VCO2 as compared to controls

impaired glucose tolerance ( J:210298 )

♂ • glucose clearance rate is lower than controls during glucose tolerance test

increased cholesterol level ( J:210298 )

♂ • total cholesterol is increased as compared to controls

increased triglyceride level ( J:210298 )

♂

decreased basal metabolism ( J:210298 )

♂ • heat production is decreased as compared to controls

liver/biliary system

enlarged liver ( J:210298 )

♂

hepatic steatosis ( J:210298 )

♂

pale liver ( J:210298 )

♂

Genotype
MGI:5572833

tg2

• Allelic Composition: Tg(Gh-Gal)4599Vron/?
• Genetic Background: involves: C57BL/6 * CD-1 * SJL

endocrine/exocrine glands

pituitary gland hyperplasia ( J:86486 )

• pituitary gland is visibly larger in transgenic animals by 12 months of age

increased pituitary adenoma incidence ( J:86486 )

• pituitary adenomas are observed in mice at 8 months of age

homeostasis/metabolism

increased circulating prolactin level ( J:86486 )

• prolactin serum levels are increased in both sexes, but the increase is greater in males (9 fold versus 2 fold)

• increase in prolactin serum levels is correlated with increase in galanin serum levels in male transgenic mice

increased circulating growth hormone level ( J:86486 )

♂ • growth hormone levels are increased in both sexes, but the increase is only significant in males

nervous system

pituitary gland hyperplasia ( J:86486 )

• pituitary gland is visibly larger in transgenic animals by 12 months of age

increased pituitary adenoma incidence ( J:86486 )

• pituitary adenomas are observed in mice at 8 months of age

neoplasm

increased pituitary adenoma incidence ( J:86486 )

• pituitary adenomas are observed in mice at 8 months of age