Phenotypes associated with this allele

• Allele Symbol: Irag1^tm1Jens
• Allele Name: targeted mutation 1, Jens Schlossmann
• Allele ID: MGI:3525059
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irag1^tm1Jens/Irag1^tm1Jens	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3526873
ht2	Irag1^tm1Jens/Irag1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3526874

Genotype
MGI:3526873

hm1

• Allelic Composition: Irag1^tm1Jens/Irag1^tm1Jens
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94387 )

• about 50% of homozygotes die before 6 months of age

cardiovascular system

decreased heart rate ( J:94387 )

• heart rate is slightly decreased to 572.8 beats per minute compared to 601.9 in wild-type mice

decreased systemic arterial blood pressure ( J:94387 )

• blood pressure is 80 mmHg compared to 93.2 mmHg in wild-type mice

digestive/alimentary system

pyloric stenosis ( J:94387 )

gastric hypertrophy ( J:94387 )

• the stomach is distended and stomach weight is increased to 4.5% of body weight compared to 1.5% in wild-type

abnormal intestinal transit time ( J:94387 )

• the passage of barium sulphate through the intestine is slowed with some retained in the stomach after 30 minutes

muscle

impaired smooth muscle contractility ( J:94387 )

• no phasic contraction response or relaxation is seen after exposure to cGMP in smooth muscle from the colon and little or no relaxation is seen in cGMP exposed phenylephrine-precontracted aortic segments

• cGMP has no effect on Ca²⁺ transients in mutant smooth muscle unlike in wild-type smooth muscle

Genotype
MGI:3526874

ht2

• Allelic Composition: Irag1^tm1Jens/Irag1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

muscle

impaired smooth muscle contractility ( J:94387 )

• cGMP only partially relaxes phenylephrine-precontracted aortic segments