Phenotypes associated with this allele

• Allele Symbol: Tg(Dct-Grm1)ESzc
• Allele Name: transgene insertion E, Suzie Chen
• Allele ID: MGI:3525118
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Dct-Grm1)ESzc/0	C57BL/6J-Tg(Dct-Grm1)ESzc	MGI:5803980
tg2	Tg(Dct-Grm1)ESzc/0	involves: C57BL/6J	MGI:5432230

Genotype
MGI:5803980

tg1

• Allelic Composition: Tg(Dct-Grm1)ESzc/0
• Genetic Background: C57BL/6J-Tg(Dct-Grm1)ESzc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased intraocular melanoma incidence ( J:230115 )

• mice develop spontaneous uveal melanoma by 8 months of age, with eyes showing ciliary body tumors with adjacent infiltration of the sclera by melanocytes

• melanocytic tumors are localized at the basis of the pars plicata of the ciliary body

• 2 of 6 eyes show tumor infiltration into the vitreous body

cellular

abnormal melanocyte proliferation ( J:230115 )

• mild to severe uveal melanocytic proliferation

pigmentation

abnormal melanocyte proliferation ( J:230115 )

• mild to severe uveal melanocytic proliferation

increased melanocyte number ( J:230115 )

• 7-8 month old eyes exhibit accumulation of melanocytes in the optic choroid, the iris, the optic nerve, the outer segments of photoreceptors, and in the surrounding of the episcleral veins and invasion into the episcleral veins and into the trabecular meshwork

vision/eye

increased intraocular melanoma incidence ( J:230115 )

• mice develop spontaneous uveal melanoma by 8 months of age, with eyes showing ciliary body tumors with adjacent infiltration of the sclera by melanocytes

• melanocytic tumors are localized at the basis of the pars plicata of the ciliary body

• 2 of 6 eyes show tumor infiltration into the vitreous body

abnormal ciliary body morphology ( J:230115 )

• remaining ciliary body is atrophic

anterior iris synechia ( J:230115 )

• all eyes have anterior synechia between the iris and the cornea, resulting in a closure of the chamber angle

retina degeneration ( J:230115 )

• retina is degenerated in the inner nuclear layer and/or the outer nuclear layer in eyes that show tumor infiltration into the vitreous body

retina detachment ( J:230115 )

• retina is focally detached in eyes that show tumor infiltration into the vitreous body

abnormal optic choroid morphology ( J:230115 )

• mice at 7-8 months of age show thickening of the choroid with numerous atypical melanocytes

• thickened choroids are due to melanocytic proliferation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
uveal melanoma		DOID:6039	OMIM:155720 OMIM:606660 OMIM:606661	J:230115

Genotype
MGI:5432230

tg2

• Allelic Composition: Tg(Dct-Grm1)ESzc/0
• Genetic Background: involves: C57BL/6J

pigmentation

abnormal melanocyte proliferation ( J:83183 )

• hyperproliferation in the pinnae and tail

hyperpigmentation ( J:83183 )

• pinnae, tail, limbs, around snout, eyelid and submandibular and inguinal lymph nodes

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

increased tail pigmentation ( J:83183 )

• hyperpigmented lesions

neoplasm

increased cutaneous melanoma incidence ( J:83183 )

• flat hyperpigmented lesions develop into raised melanomas on the pinnae and tail

• occasionally on the eye lid

immune system

enlarged inguinal lymph nodes ( J:83183 )

enlarged submandibular lymph nodes ( J:83183 )

cellular

abnormal melanocyte proliferation ( J:83183 )

• hyperproliferation in the pinnae and tail

craniofacial

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

hearing/vestibular/ear

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

integument

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

increased tail pigmentation ( J:83183 )

• hyperpigmented lesions

increased cutaneous melanoma incidence ( J:83183 )

• flat hyperpigmented lesions develop into raised melanomas on the pinnae and tail

• occasionally on the eye lid

limbs/digits/tail

increased tail pigmentation ( J:83183 )

• hyperpigmented lesions

growth/size/body

increased ear pigmentation ( J:83183 )

• hyperpigmented lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:83183