Phenotypes associated with this allele

• Allele Symbol: Pf4^tm1Mako
• Allele Name: targeted mutation 1, M Anna Kowalska
• Allele ID: MGI:3525230
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pf4^tm1Mako/Pf4^tm1Mako	B6.129X1-Pf4^tm1Mako	MGI:3526525
ht2	Pf4^tm1Mako/Pf4^+	B6.129X1-Pf4^tm1Mako	MGI:3526526

Genotype
MGI:3526525

hm1

• Allelic Composition: Pf4^tm1Mako/Pf4^tm1Mako
• Genetic Background: B6.129X1-Pf4^tm1Mako

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thrombocytosis ( J:94900 )

• the mean steady state platelet count is 1.40 x 10⁹/ml compared to 1.22 x 10⁹/ml in wild-type mice, a significant increase

homeostasis/metabolism

decreased susceptibility to induced thrombosis ( J:94900 )

• following FeCl₃ induced vascular injury the time to thrombus formation is significantly increased, the stability of thrombi formed is decreased and less than 20% of homozygotes form stable thrombi compared to 85% of wild-type mice

Genotype
MGI:3526526

ht2

• Allelic Composition: Pf4^tm1Mako/Pf4⁺
• Genetic Background: B6.129X1-Pf4^tm1Mako

hematopoietic system

thrombocytosis ( J:94900 )

• the mean steady state platelet count is 1.34 x 10⁹/ml compared to 1.22 x 10⁹/ml in wild-type mice, a significant increase

homeostasis/metabolism

decreased susceptibility to induced thrombosis ( J:94900 )

• following FeCl₃ induced vascular injury the time to thrombus formation is significantly increased, the stability of thrombi formed is decreased and less than 50% of heterozygotes form stable thrombi compared to 85% of wild-type mice