All Phenotypes Tg(Hoxb7-cre)5526Cmb MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Hoxb7-cre)5526Cmb
transgene insertion 5526, Carlton M Bates
MGI:3525255

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm2Mak/Pten^tm2Mak Tg(Hoxb7-cre)5526Cmb/0	involves: 129P2/OlaHsd	MGI:5295219
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tg(Hoxb7-cre)5526Cmb/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5438034
cn3	Trpm7^tm1Clph/Trpm7^tm1Clph Tg(Hoxb7-cre)5526Cmb/0	involves: 129S4/SvJae	MGI:6220897
cn4	Atp6ap2^tm1.1Aich/Atp6ap2^tm1.1Aich Tg(Hoxb7-cre)5526Cmb/0	involves: C57BL/6	MGI:6357730
cn5	Dmbt1^tm2Qaa/Dmbt1^tm2Qaa Tg(Hoxb7-cre)5526Cmb/0	involves: C57BL/6 * FVB/N	MGI:4868735
cn6	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm1Dor/Fgfr2⁺ Tg(Hoxb7-cre)5526Cmb/0	involves: FVB/N	MGI:3525679
cn7	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm1Dor/Fgfr2^tm1Dor Tg(Hoxb7-cre)5526Cmb/0	involves: FVB/N	MGI:3525690
cn8	Fgfr1^tm1Jpa/Fgfr1⁺ Fgfr2^tm1Dor/Fgfr2^tm1Dor Tg(Hoxb7-cre)5526Cmb/0	involves: FVB/N	MGI:3525687

Allelic Composition	Pten^tm2Mak/Pten^tm2Mak Tg(Hoxb7-cre)5526Cmb/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2Mak mutation (4 available); any Pten mutation (88 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:122953 )

• a sharp decline in survival is noted after P15

• none of the mice survive beyond 26 days of life

growth/size/body

decreased body size ( J:122953 )

• at 2 wks of age, mice are readily identified by their smaller body size and sickly appearance

renal/urinary system

abnormal kidney collecting duct morphology ( J:122953 )

• neonatal kidneys display kinked collecting ducts

• DBA staining of collecting tubules within the cortex indicates higher density and cystic morphology

abnormal renal glomerulus morphology ( J:122953 )

• at P14, the density of glomeruli within the outermost cortical layer is significantly increased

• at P14, most glomeruli are small and unevenly positioned within the cortex (i.e. subcapsular)

abnormal glomerular capillary morphology ( J:122953 )

• at P14, aberrant subcapsular glomeruli show little evidence of capillary blood flow

impaired branching involved in ureteric bud morphogenesis ( J:122953 )

• in vitro, E11.5 kidneys cultured for 48 hrs in serum free media display subtle branching defects including asymmetric ureteric bud tips that are often dilated, abnormally enlarged misshapen ampullae, discontinuous and jagged laminin basement membranes, kinked ureteric bud stalks and small ectopic bud outgrowths

• neonatal kidneys exhibit terminal end buds that are often dilated and connected to misshaped stalks

ectopic ureteric bud ( J:122953 )

• in vitro, E11.5 kidneys cultured for 48 hrs in serum free media display small ectopic bud outgrowths

cardiovascular system

abnormal glomerular capillary morphology ( J:122953 )

• at P14, aberrant subcapsular glomeruli show little evidence of capillary blood flow

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tg(Hoxb7-cre)5526Cmb/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:136068 )

• mutant pups reach term but die within 24 hrs of birth

renal/urinary system

decreased kidney cell proliferation ( J:136068 )

• at E12.5, reduced cell proliferation is noted in both ureteric and metanephric mesenchyme cells

• a modest (1.7-fold) decrease in ureteric bud cell proliferation is observed

abnormal kidney morphology ( J:136068 )

• 57% of newborn pups exhibit bilateral tiny dysplastic kidney rudiments which are deficient in nephrons, collecting ducts, and cortico-medullary patterning

• a dysgenetic kidney phenotype is histologically evident at E13.5

increased metanephric mesenchyme apoptosis ( J:136068 )

• at E12.5, metanephric mesenchyme cell apoptosis is increased 3.8-fold relative to that in wild-type controls

• in contrast, ureteric bud epithelial cell apoptosis is not significantly altered

decreased kidney collecting duct number ( J:136068 )

• at P0, dysplastic kidney rudiments are deficient in collecting ducts

absent nephrogenic zone ( J:136068 )

• at P0, newborn pups with dysplastic kidney rudiments lack a nephrogenic zone

small kidney ( J:136068 )

• at P0, dysplastic kidney rudiments are tiny

• at E12.5, mutant kidneys are slightly smaller than wild-type but histologically normal

decreased nephron number ( J:136068 )

• at P0, dysplastic kidney rudiments exhibit very few nephron structures

absent kidney ( J:136068 )

• 43% of newborn pups exhibit bilateral renal aplasia

hydroureter ( J:136068 )

• at P0, newborn pups with dysplastic kidney rudiments exhibit hydroureter

impaired branching involved in ureteric bud morphogenesis ( J:136068 )

• at E12.5, mutant kidneys show a highly attenuated ureteric branching pattern relative to wild-type kidneys

• by E13.5, ureteric bud tissue is reduced and developing nephrogenic structures are absent

• however, normal junctional complexes and adherens junctions are present in the epithelial cells of the ureteric bud at E13.5

cellular

increased metanephric mesenchyme apoptosis ( J:136068 )

• at E12.5, metanephric mesenchyme cell apoptosis is increased 3.8-fold relative to that in wild-type controls

• in contrast, ureteric bud epithelial cell apoptosis is not significantly altered

decreased kidney cell proliferation ( J:136068 )

• at E12.5, reduced cell proliferation is noted in both ureteric and metanephric mesenchyme cells

• a modest (1.7-fold) decrease in ureteric bud cell proliferation is observed

embryo

increased metanephric mesenchyme apoptosis ( J:136068 )

• at E12.5, metanephric mesenchyme cell apoptosis is increased 3.8-fold relative to that in wild-type controls

• in contrast, ureteric bud epithelial cell apoptosis is not significantly altered

Allelic Composition	Trpm7^tm1Clph/Trpm7^tm1Clph Tg(Hoxb7-cre)5526Cmb/0
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Hoxb7-cre)5526Cmb mutation (0 available)
Trpm7^tm1Clph mutation (1 available); any Trpm7 mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:181963 )

N	• at P12, mice exhibit normal kidney size and histology relative to control mice, suggesting normal kidney development

Allelic Composition	Atp6ap2^tm1.1Aich/Atp6ap2^tm1.1Aich Tg(Hoxb7-cre)5526Cmb/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6ap2^tm1.1Aich mutation (0 available); any Atp6ap2 mutation (10 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney cyst ( J:223201 )

• presence of occasional cysts in the medullary collecting ducts at P1

decreased urine osmolality ( J:223201 )

• urine osmolalities are lower

increased urine pH ( J:223201 )

• baseline urine pH is normal but is higher following 48 hours of acidic loading with NH4Cl, indicating a lower ability to handle an acidic load

abnormal kidney collecting duct morphology ( J:223201 )

• collecting ducts show increased apoptosis at E18.5

dilated kidney collecting duct ( J:223201 )

• dilation of tubules from a proximal tubule origin at P1

abnormal kidney cortex morphology ( J:223201 )

• thin kidney cortex at P1

small kidney ( J:223201 )

• small kidney size in newborns

decreased kidney weight ( J:223201 )

• kidney weight and kidney-to-body weight ratios are lower at P1 at P30

renal hypoplasia ( J:223201 )

decreased nephron number ( J:223201 )

• decrease in nephron number at P1

abnormal ureteric bud morphology ( J:223201 )

• ureteric buds show increased apoptosis at E12.5

abnormal metanephric ureteric bud development ( J:223201 )

• kidneys show aberrant terminal differentiation of the ureteric bud epithelium

impaired branching involved in ureteric bud morphogenesis ( J:223201 )

• E12.5 metanephroi show a reduction in the number of ureteric bud tips indicating a branching defect

polyuria ( J:223201 )

• 24-hour urine volumes are higher despite similar water intake

homeostasis/metabolism

increased circulating creatinine level ( J:223201 )

• levels of serum creatinine are increased at P30

decreased urine osmolality ( J:223201 )

• urine osmolalities are lower

increased urine pH ( J:223201 )

• baseline urine pH is normal but is higher following 48 hours of acidic loading with NH4Cl, indicating a lower ability to handle an acidic load

growth/size/body

kidney cyst ( J:223201 )

• presence of occasional cysts in the medullary collecting ducts at P1

Allelic Composition	Dmbt1^tm2Qaa/Dmbt1^tm2Qaa Tg(Hoxb7-cre)5526Cmb/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmbt1^tm2Qaa mutation (0 available); any Dmbt1 mutation (111 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating bicarbonate level ( J:167156 )

metabolic acidosis ( J:167156 )

• metabolic acidosis

renal tubular acidosis ( J:167156 )

increased urine pH ( J:167156 )

renal/urinary system

renal tubular acidosis ( J:167156 )

increased urine pH ( J:167156 )

abnormal kidney cortex morphology ( J:167156 )

• in the kidney cortex, beta-intercalated cells are replaced with alpha-intercalated cells unlike in wild-type mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:167156 )

N	• mice exhibit normal compound action potentials

Allelic Composition	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm1Dor/Fgfr2⁺ Tg(Hoxb7-cre)5526Cmb/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:95018 )

N	• normal kidneys and no apparent renal abnormalities

Allelic Composition	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm1Dor/Fgfr2^tm1Dor Tg(Hoxb7-cre)5526Cmb/0
Genetic Background	involves: FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

decreased renal glomerulus number ( J:95018 )

• reduced numbers of glomeruli in both embryonic and adult kidneys

hydronephrosis ( J:95018 )

• some adult mutants had hydronephrosis occurring unilaterally or bilaterally

small kidney ( J:95018 )

• E13.5 and E16.5 kidneys were smaller than controls

• many adult mutants had small, abnormally shaped kidneys

abnormal ureteric bud morphology ( J:95018 )

• E11.5 ureteric bud explants had abnormally thin, long ureteric stalks and fewer peripheral tips, with a range in phenotype severity

• decrease in the mean number of ureteric bud tips on the surface of E16.5 kidneys

• range of ureteric bud defects at E16.5, including extremely small kidneys with large areas devoid of ureteric tissue

Allelic Composition	Fgfr1^tm1Jpa/Fgfr1⁺ Fgfr2^tm1Dor/Fgfr2^tm1Dor Tg(Hoxb7-cre)5526Cmb/0
Genetic Background	involves: FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

decreased renal glomerulus number ( J:95018 )

• 22% and 24% fewer glomeruli in E11.5 explants and adult kidneys, respectively

abnormal kidney development ( J:95018 )

• defects in cortical stromal mesenchyme patterning, showing aberrantly thickened stroma in subcapsular regions in E13.5 kidneys and regions of massive subcapsular apoptosis in stroma

• absent intercalated stripes of stromal cells in E13.5 kidneys

hydronephrosis ( J:95018 )

• 20% of adult mutants had hydronephrosis occurring unilaterally or bilaterally

small kidney ( J:95018 )

• E13.5 and E16.5 kidneys were smaller than controls

• 80% of adult mutants had small, abnormally shaped kidneys

abnormal ureteric bud morphology ( J:95018 )

• range of ureteric bud defects at E16.5, including extremely small kidneys with large areas devoid of ureteric tissue

• increased apoptotic nuclei in ureteric buds (2-3 apoptotic nuclei compared to none or just one in controls)

• decreased rates of proliferation in ureteric bud tips compared with controls

impaired branching involved in ureteric bud morphogenesis ( J:95018 )

• E11.5 ureteric bud explants exhibited aberrant branching and had abnormally thin, long ureteric stalks and fewer peripheral tips, with a range in phenotype severity

• decrease in the mean number of ureteric bud tips on the surface of E16.5 kidneys (89.5 versus 271 in control)

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