Phenotypes associated with this allele

• Allele Symbol: Il27ra^tm1Fjs
• Allele Name: targeted mutation 1, Frederic J de Sauvage
• Allele ID: MGI:3525439
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il27ra^tm1Fjs/Il27ra^tm1Fjs	B6.Cg-Il27ra^tm1Fjs	MGI:3526304

Genotype
MGI:3526304

hm1

• Allelic Composition: Il27ra^tm1Fjs/Il27ra^tm1Fjs
• Genetic Background: B6.Cg-Il27ra^tm1Fjs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased lymphocyte cell number ( J:94856 )

• increased lymphocyte accumulation within the lung granulomata during M. tuberculosis infection compared to wild-type

abnormal T-helper 1 physiology ( J:94856 )

• amount of interferon-gamma production was decreased per lung-derived CD4 T cell and per antigen-specific CD4 T cell, but not in spleen-derived CD4 T cell, after M. tuberculosis infection

decreased susceptibility to bacterial infection ( J:94856 )

• improved control of Mycobacterium tuberculosis growth and improved reduction of bacterial burden in the lungs, spleen, and draining lymph node

hematopoietic system

increased lymphocyte cell number ( J:94856 )

• increased lymphocyte accumulation within the lung granulomata during M. tuberculosis infection compared to wild-type

abnormal T-helper 1 physiology ( J:94856 )

• amount of interferon-gamma production was decreased per lung-derived CD4 T cell and per antigen-specific CD4 T cell, but not in spleen-derived CD4 T cell, after M. tuberculosis infection