Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-cre)7Mul
• Allele Name: transgene insertion 7, William J Muller
• Allele ID: MGI:3525443
• Summary: 18 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdh1^tm2Kem/Cdh1^+ Smad4^tm2.1Cxd/Smad4^tm2.1Cxd Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)7Mul/0	involves: 129 * C57BL/6 * FVB/N	MGI:5634403
cn2	Smad4^tm2.1Cxd/Smad4^tm2.1Cxd Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)7Mul/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N	MGI:5634404
cn3	Erbb2^tm8(Erbb2)Mul/Erbb2^+ Pten^tm1Hwu/Pten^+ Tg(MMTV-cre)7Mul/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N	MGI:4839508
cn4	Erbb2^tm8(Erbb2)Mul/Erbb2^+ Pten^tm1Hwu/Pten^tm1Hwu Tg(MMTV-cre)7Mul/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N	MGI:4839510
cn5	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Src^tm1Mul/Src^tm1Mul Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)#Mul/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N	MGI:5314779
cn6	Sfn^tm1Mul/Sfn^tm1Mul Tg(MMTV-cre)7Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4452139
cn7	Erbb2^tm8(Erbb2)Mul/Erbb2^+ Tg(MMTV-cre)7Mul/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3714371
cn8	Src^tm1Mul/Src^tm1Mul Tg(MMTV-cre)7Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5314776
cn9	Src^tm1Mul/Src^+ Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)#Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5314777
cn10	Src^tm1Mul/Src^tm1Mul Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)#Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5314778
cn11	Pten^tm1Hwu/Pten^tm1Hwu Tg(MMTV-cre)7Mul/0	involves: 129S4/SvJae * FVB/N	MGI:4839512
cn12	Ets2^tm3Rgo/Ets2^tm3Rgo Meox2^tm1(cre)Sor/? Tg(MMTV-cre)7Mul/?	involves: 129S4/SvJaeSor * FVB/N	MGI:3615264
cn13	Ets2^tm3Rgo/Ets2^+ Meox2^tm1(cre)Sor/? Tg(MMTV-cre)7Mul/?	involves: 129S4/SvJaeSor * FVB/N	MGI:3615265
cn14	Erbb3^tm1Squ/Erbb3^tm1Squ Tg(MMTV-cre)7Mul/0	involves: 129S6/SvEvTac * FVB/N	MGI:3691287
cn15	Itgb1^tm1Mll/Itgb1^tm1Mll Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)634Mul/0	involves: 129X1/SvJ * FVB/N	MGI:3704008
cn16	Itgb1^tm1Mll/Itgb1^tm1Mll Tg(MMTV-cre)7Mul/0	involves: 129X1/SvJ * FVB/N	MGI:3704007
cn17	Gt(ROSA)26Sor^tm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor^+ Tg(MMTV-cre)7Mul/0	involves: BALB/c * FVB/N	MGI:5052139
cn18	Dock1^tm2.1Jfco/Dock1^tm2.1Jfco Tg(MMTV-cre)7Mul/0	involves: C57BL/6 * FVB/N * FVB/NJ	MGI:5515764

Genotype
MGI:5634403

cn1

• Allelic Composition: Cdh1^tm2Kem/Cdh1⁺; Smad4^tm2.1Cxd/Smad4^tm2.1Cxd; Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:212549 )

• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age

• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen

increased metastatic potential ( J:212549 )

• 33% of mice show lung metastasis

integument

increased mammary adenocarcinoma incidence ( J:212549 )

• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age

• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:212549 )

• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age

• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen

Genotype
MGI:5634404

cn2

• Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd; Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

neoplasm

increased mammary adenocarcinoma incidence ( J:212549 )

• mice develop mammary gland carcinoma with a median tumor-free survival of 12.1 months of age

increased metastatic potential ( J:212549 )

• 35.7% of mice show lung metastasis

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:212549 )

• mice develop mammary gland carcinoma with a median tumor-free survival of 12.1 months of age

integument

increased mammary adenocarcinoma incidence ( J:212549 )

• mice develop mammary gland carcinoma with a median tumor-free survival of 12.1 months of age

Genotype
MGI:4839508

cn3

• Allelic Composition: Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺; Pten^tm1Hwu/Pten⁺; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

increased metastatic potential ( J:133305 )

• 35% incidence of lung metastases compared with 5% in single Erbb2 mutants

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

integument

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:133305

Genotype
MGI:4839510

cn4

• Allelic Composition: Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

integument

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:133305

Genotype
MGI:5314779

cn5

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Src^tm1Mul/Src^tm1Mul; Tg(MMTV-cre)7Mul/0; Tg(MMTV-PyVT)#Mul/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N

neoplasm

neoplasm ( J:181822 )

N • mice exhibit the same incidence of lung metastases and average metastatic burden as in Tg(MMTV-PyVT)#Mul mice

Genotype
MGI:4452139

cn6

• Allelic Composition: Sfn^tm1Mul/Sfn^tm1Mul; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

endocrine/exocrine glands

abnormal mammary gland epithelium morphology ( J:159517 )

♀ • multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals

♀ • unaffected mammary ductal outgrowth

♀ • threefold increase in the proliferative capacity of the luminal mammary epithelial cell

♀ • unaffected rate of apoptotic cell death in mammary epithelial cells

♀ • disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures

♀ • decreased percentage of polarized epithelial cells

♀ • isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells

♀ • dramatically reduced percentage of polarized cysts compared with wild-type controls in 3D Matrigel cultures

abnormal mammary gland duct morphology ( J:159517 )

♀ • multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals

♀ • isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells

cellular

abnormal cell adhesion ( J:159517 )

• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures

• decreased percentage of polarized epithelial cells

increased cell proliferation ( J:159517 )

• threefold increase in the proliferative capacity of the luminal mammary epithelial cell

integument

abnormal mammary gland epithelium morphology ( J:159517 )

♀ • multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals

♀ • unaffected mammary ductal outgrowth

♀ • threefold increase in the proliferative capacity of the luminal mammary epithelial cell

♀ • unaffected rate of apoptotic cell death in mammary epithelial cells

♀ • disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures

♀ • decreased percentage of polarized epithelial cells

♀ • isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells

♀ • dramatically reduced percentage of polarized cysts compared with wild-type controls in 3D Matrigel cultures

abnormal mammary gland duct morphology ( J:159517 )

♀ • multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals

♀ • isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells

Genotype
MGI:3714371

cn7

• Allelic Composition: Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺; Tg(MMTV-cre)7Mul/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

endocrine/exocrine glands

abnormal mammary gland development ( J:61202 )

♀ • numerous lobular side buds with acinar structures are observed

abnormal mammary gland lobule morphology ( J:89255 )

♀ • mice develop precocious lobualveolar hyperplasias of the mammary glands

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

neoplasm

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

integument

abnormal mammary gland development ( J:61202 )

♀ • numerous lobular side buds with acinar structures are observed

abnormal mammary gland lobule morphology ( J:89255 )

♀ • mice develop precocious lobualveolar hyperplasias of the mammary glands

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:167180

Genotype
MGI:5314776

cn8

• Allelic Composition: Src^tm1Mul/Src^tm1Mul; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Normal mammary gland branching and ductal outgrowth in Src^tm1Mul/Src^tm1Mul Tg(MMTV-cre)7Mul/0 mice

reproductive system

reproductive system phenotype ( J:181822 )

N • mice exhibit normal mammary gland branching and ductal outgrowth

Genotype
MGI:5314777

cn9

• Allelic Composition: Src^tm1Mul/Src⁺; Tg(MMTV-cre)7Mul/0; Tg(MMTV-PyVT)#Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Analysis of tumorigenesis

neoplasm

increased mammary gland tumor incidence ( J:181822 )

• with later onset than in Tg(MMTV-PyVT)#Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:181822 )

• with later onset than in Tg(MMTV-PyVT)#Mul mice

integument

increased mammary gland tumor incidence ( J:181822 )

• with later onset than in Tg(MMTV-PyVT)#Mul mice

Genotype
MGI:5314778

cn10

• Allelic Composition: Src^tm1Mul/Src^tm1Mul; Tg(MMTV-cre)7Mul/0; Tg(MMTV-PyVT)#Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Analysis of tumorigenesis

neoplasm

increased mammary gland tumor incidence ( J:181822 )

• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice

integument

increased mammary gland tumor incidence ( J:181822 )

• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:181822 )

• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice

Genotype
MGI:4839512

cn11

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S4/SvJae * FVB/N

neoplasm

neoplasm ( J:133305 )

N • mice do not develop mammary tumors over a 16 month period

Genotype
MGI:3615264

cn12

• Allelic Composition: Ets2^tm3Rgo/Ets2^tm3Rgo; Meox2^tm1(cre)Sor/?; Tg(MMTV-cre)7Mul/?
• Genetic Background: involves: 129S4/SvJaeSor * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 132 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 132 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 132 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

Genotype
MGI:3615265

cn13

• Allelic Composition: Ets2^tm3Rgo/Ets2⁺; Meox2^tm1(cre)Sor/?; Tg(MMTV-cre)7Mul/?
• Genetic Background: involves: 129S4/SvJaeSor * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 132 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 132 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 132 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

Genotype
MGI:3691287

cn14

• Allelic Composition: Erbb3^tm1Squ/Erbb3^tm1Squ; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:114524 )

♀ • ductal density is lower in 4-8 week-old virgin females

♀ • there are fewer end branches and terminal buds in mammary gland ductal system

integument

abnormal branching of the mammary ductal tree ( J:114524 )

♀ • ductal density is lower in 4-8 week-old virgin females

♀ • there are fewer end branches and terminal buds in mammary gland ductal system

Genotype
MGI:3704008

cn15

• Allelic Composition: Itgb1^tm1Mll/Itgb1^tm1Mll; Tg(MMTV-cre)7Mul/0; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

neoplasm

decreased mammary gland tumor incidence ( J:92547 )

• mammary tumors are not detected at 10 weeks of age, like they are in control mice expressing Tg(MMTV-PyVT)634Mul

• although palpable mammary tumors are detected after 4 months of age, these tumors are composed of cells which fail to express the cre transgene and thus express Itgb1

integument

decreased mammary gland tumor incidence ( J:92547 )

• mammary tumors are not detected at 10 weeks of age, like they are in control mice expressing Tg(MMTV-PyVT)634Mul

• although palpable mammary tumors are detected after 4 months of age, these tumors are composed of cells which fail to express the cre transgene and thus express Itgb1

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:92547 )

• mammary tumors are not detected at 10 weeks of age, like they are in control mice expressing Tg(MMTV-PyVT)634Mul

• although palpable mammary tumors are detected after 4 months of age, these tumors are composed of cells which fail to express the cre transgene and thus express Itgb1

Genotype
MGI:3704007

cn16

• Allelic Composition: Itgb1^tm1Mll/Itgb1^tm1Mll; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:92547 )

N • mice with ablation of Itgb1 in the mammary epithelium show normal mammary ductual outgrowth during puberty and are able to lactate and produce viable litters through multiple rounds of pregnancy

Genotype
MGI:5052139

cn17

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-PIK3CA*H1047R,-EGFP)Balj}/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: BALB/c * FVB/N

mortality/aging

premature death ( J:173655 )

• 75% of mice die before 4 months of age

neoplasm

increased mammary adenocarcinoma incidence ( J:173655 )

• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice

• mammary tumors are heterogeneous (adenomyoepitheliomas)

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:173655 )

• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice

• mammary tumors are heterogeneous (adenomyoepitheliomas)

integument

increased mammary adenocarcinoma incidence ( J:173655 )

• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice

• mammary tumors are heterogeneous (adenomyoepitheliomas)

Genotype
MGI:5515764

cn18

• Allelic Composition: Dock1^tm2.1Jfco/Dock1^tm2.1Jfco; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: C57BL/6 * FVB/N * FVB/NJ

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:196659 )

N • mice exhibit normal mammary gland development and are capable of nursing their offspring to maturity