Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(MMTV-PyVT)#Mul transgene insertion, William J Muller MGI:3525504 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Analysis of tumorigenesis
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Analysis of tumorigenesis
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• of tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen
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• of tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen
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• tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen exhibit impaired proliferation, increased apoptosis and restored cell-cell adhesion compared to in Tg(MMTV-PyVT)#Mul mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas
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• progression to pulmonary metastases is seen in more than 95% of mice more than 130 days of age
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• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens
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• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens
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• percentage of tumor-infiltrating Treg cells is increased
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• percentage of macrophage-like populations and myeloid cells in the spleen increase with increasing tumor load, with a corresponding decrease in the percentage of T cells
• however, percentage of NKT cells in the spleen is similar to controls
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• total number of splenocytes increases progressively with increasing tumor burden
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• T cells from CD3/CD28-stimulated splenocytes from tumor-bearing mice produce lower levels of IFN-gamma
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• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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• tumor-bearing mice show increased serum levels of pro-inflammatory cytokines MCP-1 and TNF-alpha
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• in tumor-bearing mice
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• total number of lymph node cells in tumor-draining lymph nodes increases progressively until a total tumor burden between 8 and 12 cm3 is reached, after which a decrease in lymph node cell numbers is seen
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• increase in the percentages of B cells within the tumor-draining lymph nodes of mice with extensive tumor loads
• however, percentage of NKT cells in the tumor-draining lymph nodes is similar to controls
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• tumor-bearing mice show increased serum levels of pro-inflammatory cytokines MCP-1 and TNF-alpha
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• in tumor-bearing mice
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• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
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• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens
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• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens
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• percentage of tumor-infiltrating Treg cells is increased
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• myeloid cells in the spleen are increased in tumor-bearing mice
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• percentage of macrophage-like populations and myeloid cells in the spleen increase with increasing tumor load, with a corresponding decrease in the percentage of T cells
• however, percentage of NKT cells in the spleen is similar to controls
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• total number of splenocytes increases progressively with increasing tumor burden
|
|
|
• T cells from CD3/CD28-stimulated splenocytes from tumor-bearing mice produce lower levels of IFN-gamma
|
|
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• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
|
|
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• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
|
|
|
• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
|
|
|
• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens
|
|
|
• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas
|
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|
• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas
|
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• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:147923 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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