Phenotypes associated with this allele

• Allele Symbol: Btg2^tm1Spo
• Allele Name: targeted mutation 1, S Paul Oh
• Allele ID: MGI:3525505
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Btg2^tm1Spo/Btg2^tm1Spo	involves: 129S4/SvJae * C57BL/6	MGI:3526235
ht2	Btg2^tm1Spo/Btg2^+	involves: 129S4/SvJae * C57BL/6	MGI:3526237
cx3	Bmpr2^tm1Kmi/Bmpr2^+ Btg2^tm1Spo/Btg2^tm1Spo	involves: 129S4/SvJae * C57BL/6	MGI:3526247

Genotype
MGI:3526235

hm1

• Allelic Composition: Btg2^tm1Spo/Btg2^tm1Spo
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

vertebral transformation ( J:95124 )

• the sacral vertebrae begin at vertebra 26 instead of vertebra 27

thoracic vertebral transformation ( J:95124 )

• rib rudiments in the 20th vertebra were minute or completely absent, indicating a transformation of the 13th thoracic vertebra (T13) to the first lumbar vertebra

cervical vertebral transformation ( J:95124 )

• 6/22 homozygotes had the first set of ribs attached to the 7th rather than the 8th vertebra, indicating a transformation of the 7th cervical vertebra (C7) to the first thoracic vertebra

Genotype
MGI:3526237

ht2

• Allelic Composition: Btg2^tm1Spo/Btg2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

skeleton

vertebral transformation ( J:95124 )

• heterozygotes exhibited similar, but less intense, vertebral abnormalities as homozygotes

Genotype
MGI:3526247

cx3

• Allelic Composition: Bmpr2^tm1Kmi/Bmpr2⁺; Btg2^tm1Spo/Btg2^tm1Spo
• Genetic Background: involves: 129S4/SvJae * C57BL/6

skeleton

vertebral transformation ( J:95124 )

• mutants exhibited similar vertebral abnormalities as single homozygous Btg2 mutants, with no differences in the severity of phenotype