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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lcn2tm1Aade
targeted mutation 1, Alan Aderem
MGI:3525578
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lcn2tm1Aade/Lcn2tm1Aade B6.129P2-Lcn2tm1Aade MGI:6103903
hm2
Lcn2tm1Aade/Lcn2tm1Aade involves: 129P2/OlaHsd * C57BL/6 MGI:3526061


Genotype
MGI:6103903
hm1
Allelic
Composition
Lcn2tm1Aade/Lcn2tm1Aade
Genetic
Background
B6.129P2-Lcn2tm1Aade
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcn2tm1Aade mutation (1 available); any Lcn2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cold exposed female mice exhibit reduced body temperature and die after 12 hours unlike wild-type mice while male mice exhibit a non-significant trend
• in mice fed a high-fat or regular chow diet
• in mice fed a high-fat or regular chow diet
• in mice fed a regular chow diet
• in mice fed a high-fat diet
• mice fed a high-fat diet exhibit more severe diet-induced glucose intolerance compared with wild-type mice
• however, glucose tolerance is normal when mice are fed a regular chow diet
• mice fed a high-fat diet or regular chow diet exhibit more severe diet-induced insulin resistance compared with wild-type mice
• in mice fed a high-fat diet
• however, serum levels of leptin and plasminogen activator inhibitor-1 are normal
• in mice fed a high-fat diet and aged

adipose tissue
• in mice fed a high-fat diet and aged
• in mice fed a high-fat diet and aged
• at 15 weeks of age

growth/size/body
• in mice fed a high-fat diet and aged
• in mice fed a high-fat diet and aged
• in mice fed a high-fat diet and aged
• in mice fed a high-fat diet and aged

cardiovascular system
• in mice fed a high-fat diet and aged

hematopoietic system
• in mice fed a high-fat diet and aged

immune system
• in mice fed a high-fat diet and aged

liver/biliary system
• in mice fed a high-fat diet and aged
• in mice fed a high-fat diet and aged
• in mice fed a high-fat diet and aged

renal/urinary system
• in mice fed a high-fat diet and aged




Genotype
MGI:3526061
hm2
Allelic
Composition
Lcn2tm1Aade/Lcn2tm1Aade
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcn2tm1Aade mutation (1 available); any Lcn2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• within 42 hours after E.coli H9049 infection, more than 80% of homozygotes died compared to 0% of wild-type

immune system
• increased susceptibility to infection with bacteria that acquire iron through enterochelin-type siderophores (such as E.coli) but not with those that do not (such as S. aureus)
• increased bacteraemia and bacterial burden in the liver and spleen after intraperitoneal challenge with E. coli, strain H9049 compared to controls, however no differences in leukocyte numbers, neutrophil infiltration, or iron distribution





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory