Analysis Tools
limbs/digits/tail
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• two fewer than in wild-type mice
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skeleton
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• two fewer than in wild-type mice
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• mice lack distinct sternebrae unlike in wild-type mice
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• the first rib does not always attach to the sternum unlike in wild-type mice
• rib attachment to the sternum continues past T7 to T13 and the transformed 'T14'
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• posterior rib growth is abnormal with 4 vertebrae posterior to T13 forming ribs
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rib fusion
(
J:124112
)
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• distal fusion of anterior-most ribs
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• shifted posteriorly with displacement of pelvic attachment
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• mice exhibit anterior homeotic transformations through the posterior thoracic skeleton and into the lumbar region
• the axial skeleton posterior to the transformations are shifted caudally by two vertebral segments
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• T8 through L2 exhibit a T7-like phenotype
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• T8 through L2 exhibit a T7-like phenotype
• L5 has an L3-like phenotype
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• the sternum is ossified and mispatterened along its entire anterior posterior length
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