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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cnga2tm1Reed
targeted mutation 1, Randall R Reed
MGI:3525590
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cnga2tm1Reed/Cnga2+ involves: 129/Sv * BALB/cJ MGI:3717668
ot2
 		Cnga2tm1Reed/Y involves: 129/Sv * BALB/cJ MGI:3717667


Genotype
MGI:3717668
ht1
Allelic
Composition		 Cnga2tm1Reed/Cnga2+
Genetic
Background		 involves: 129/Sv * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Reed mutation (0 available); any Cnga2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:77304 )
• Cgna2+ olfactory neurons positive for the reporter are depleted
• however, naris occlusion prevents loss of neurons

craniofacial
abnormal olfactory sensory neuron morphology ( J:77304 )
• Cgna2+ olfactory neurons positive for the reporter are depleted
• however, naris occlusion prevents loss of neurons

respiratory system
abnormal olfactory sensory neuron morphology ( J:77304 )
• Cgna2+ olfactory neurons positive for the reporter are depleted
• however, naris occlusion prevents loss of neurons

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:77304 )
• Cgna2+ olfactory neurons positive for the reporter are depleted
• however, naris occlusion prevents loss of neurons

growth/size/body
abnormal olfactory sensory neuron morphology ( J:77304 )
• Cgna2+ olfactory neurons positive for the reporter are depleted
• however, naris occlusion prevents loss of neurons




Genotype
MGI:3717667
ot2
Allelic
Composition		 Cnga2tm1Reed/Y
Genetic
Background		 involves: 129/Sv * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Reed mutation (0 available); any Cnga2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:77304 )
N
• mice exhibit normal olfactory epithelium and bulb
abnormal sensory neuron physiology ( J:77304 )
• odorant-evoked activity is essentially eliminated compared with wild-type mice

taste/olfaction
abnormal olfactory system physiology ( J:77304 )
• odorant-evoked activity in response to amyl acetate, isovaleric acid, octanal and heptanal is lost




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory