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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdh2Gt(OST49160)Lex
gene trap OST149160, Lexicon Genetics
MGI:3525642
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex involves: 129S5/SvEvBrd MGI:3525861
cn2
 		Cdh2tm1Glr/Cdh2Gt(OST49160)Lex
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ 		involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N MGI:3580161


Genotype
MGI:3525861
hm1
Allelic
Composition		 Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh2Gt(OST49160)Lex mutation (1 available); any Cdh2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:95209 )
• embryonic lethality as seen in homozygous null Cdh2tm1Hyn mice

cardiovascular system
abnormal heart tube morphology ( J:95209 )
• exhibited an identical phenotype to the Cdh2-null allele, Cdh2tm1Hyn
• at E9.5, had a malformed heart tube that consisted of rounded and dissociated myocytes surrounding the endocardium
pericardial edema ( J:95209 )
• severe pericardial swelling at E9

homeostasis/metabolism
pericardial edema ( J:95209 )
• severe pericardial swelling at E9

nervous system
abnormal brain development ( J:95209 )
• homozygotes showed a lack of brain development




Genotype
MGI:3580161
cn2
Allelic
Composition		 Cdh2tm1Glr/Cdh2Gt(OST49160)Lex
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Cdh2Gt(OST49160)Lex mutation (1 available); any Cdh2 mutation (51 available)
Cdh2tm1Glr mutation (1 available); any Cdh2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:98828 )
• mutants die about 2 months after tamoxifen treatment

cardiovascular system
abnormal myocardial fiber morphology ( J:98828 )
• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen
• after tamoxifen treatment intercalated disc structures and intercellular space are absent
• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines
abnormal intercalated disk morphology ( J:98828 )
• after tamoxifen treatment intercalated disc structures are absent
dilated heart atrium ( J:98828 )
• modest dilation of the atria after tamoxifen treatment
abnormal heart shape ( J:98828 )
• after tamoxifen treatment hearts appear elongated and flacid
dilated heart left ventricle ( J:98828 )
• modest dilation of the ventricles after tamoxifen treatment
dilated heart right ventricle ( J:98828 )
• modest dilation of the ventricles after tamoxifen treatment
decreased heart left ventricle muscle contractility ( J:98828 )
• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased
decreased heart rate ( J:98828 )
• about 5 weeks after tamoxifen treatment, mutant heart rate is significantly reduced
increased heart rate ( J:98828 )
• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death
irregular heartbeat ( J:98828 )
• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death
abnormal impulse conducting system conduction ( J:98828 )
• tachyarrhythmia is initiated by premature ventricular depolarization

muscle
abnormal myocardial fiber morphology ( J:98828 )
• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen
• after tamoxifen treatment intercalated disc structures and intercellular space are absent
• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines
abnormal intercalated disk morphology ( J:98828 )
• after tamoxifen treatment intercalated disc structures are absent
decreased heart left ventricle muscle contractility ( J:98828 )
• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory