Analysis Tools|
Allele Symbol Allele Name Allele ID |
Abl1tm1Ajk targeted mutation 1, Anthony J Koleske MGI:3525886 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• only 35% of the expected Mendelian numbers are born
• those that were born survived well into adulthood
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• smaller dendrite arbors resulting in more densely packed neurons in all layers of cortex in 6-8 weeks old mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice injected with an adenovirus expressing tTA into the ventral midbrain and then treated with doxycycline show rescue of the nigral degeneration of dopamine neurons and loss of dopamine seen in single Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0 mice
• mice injected with an adenovirus expressing tTA into the ventral midbrain show prevention of the amphetamine-induced rotation, indicating that the dopamine neurons are functionally spared
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice injected with alpha-synuclein preformed fibrils show preservation of dopamine neurons and rescue of the loss of dopamine and striatal fiber density and show rescue of the pole test performance deficits and rotarod and cylinder test behavioral defects that are seen in alpha-synuclein preformed fibril injected wild-type mice
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| N |
• mice injected with alpha-synuclein preformed fibrils show rescue of the pole test performance deficits (increased time to turn and time to reach the base), and behavioral defects in the rotarod and cylinder test that are seen in wild-type mice injected with alpha-synuclein preformed fibrils
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| N |
• mice injected with alpha-synuclein preformed fibrils show preservation of dopamine neurons and rescue of the loss of dopamine and striatal fiber density that is seen in alpha-synuclein preformed fibril injected wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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