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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rictortm1Mgn
targeted mutation 1, Mark A Magnuson
MGI:3526066
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rictortm1Mgn/Rictortm1Mgn involves: 129S6/SvEvTac * C57BL/6 MGI:3706123


Genotype
MGI:3706123
hm1
Allelic
Composition
Rictortm1Mgn/Rictortm1Mgn
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rictortm1Mgn mutation (0 available); any Rictor mutation (141 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• expected Mendelian distribution ratios by E11.5
• embryonic lethality was observed at later times, and only 1 live embryo was identified among 44 embryos at E16.5

homeostasis/metabolism
• indistinguishable from either wild-type or heterozygous littermates prior to E12.5
• often displayed hydrops fetalis at later stages
• histologically normal and no major structural defects in any organ systems were found

embryo
• trophoblast giant cells number was increased and aberrantly distributed throughout the labyrinth layer in an E16.5 mutant mice
• placenta was both smaller and thinner than wild-type littermate in an E16.5 mutant mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory