All Phenotypes Kat5<tm1Jwl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kat5^tm1Jwl
targeted mutation 1, John W Lough
MGI:3526095

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat5^tm1Jwl/Kat5^tm1Jwl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3814375
cx2	Kat5^tm1Jwl/Kat5⁺ Tg(IghMyc)22Bri/0 Trp53^tm1Tyj/Trp53⁺	involves: 129 * C57BL * C57BL/6 * SJL	MGI:3814381
cx3	Kat5^tm1Jwl/Kat5⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3814378
cx4	Kat5^tm1Jwl/Kat5⁺ Tg(IghMyc)22Bri/0	involves: 129S1/Sv * 129X1/SvJ * C57BL * C57BL/6 * SJL	MGI:3814376
cx5	Cdkn2a^tm1Cjs/Cdkn2a⁺ Kat5^tm1Jwl/Kat5⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3814377

Allelic Composition	Kat5^tm1Jwl/Kat5^tm1Jwl
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation ( J:125164 )

Allelic Composition	Kat5^tm1Jwl/Kat5⁺ Tg(IghMyc)22Bri/0 Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129 * C57BL * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (28 available)
Tg(IghMyc)22Bri mutation (1 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125164 )

• mice die prior to 20 weeks of age

neoplasm

increased B cell derived lymphoma incidence ( J:125164 )

• mice exhibit an earlier age of onset and enhanced penetrance of B cell lymphomas compared to in Tg(IghMyc)22Bri mice

Allelic Composition	Kat5^tm1Jwl/Kat5⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (28 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:125164 )

• mice exhibit the same disease progression as in Trp53^tm1Tyj homozygotes

Allelic Composition	Kat5^tm1Jwl/Kat5⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (28 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125164 )

• mice die prior to 30 weeks of age

neoplasm

increased B cell derived lymphoma incidence ( J:125164 )

• mice exhibit an earlier age of onset and enhanced penetrance of B cell lymphomas compared to in Tg(IghMyc)22Bri mice

• tumor cells exhibit replacement of the knock-out allele with a wild-type allele

immune system

abnormal B cell physiology ( J:125164 )

• B cells exhibit severely impaired Myc-induced DNA damage repair

homeostasis/metabolism

abnormal DNA repair ( J:125164 )

• B cells exhibit severely impaired Myc-induced DNA damage repair

• however, DNA damage repair following ionizing radiation exposure is normal

cellular

abnormal DNA repair ( J:125164 )

• B cells exhibit severely impaired Myc-induced DNA damage repair

• however, DNA damage repair following ionizing radiation exposure is normal

hematopoietic system

abnormal B cell physiology ( J:125164 )

• B cells exhibit severely impaired Myc-induced DNA damage repair

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a⁺ Kat5^tm1Jwl/Kat5⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Cjs mutation (7 available); any Cdkn2a mutation (67 available)
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:125164 )

• mice exhibit the same early tumor onset as in Cdkn2a^tm1Cjs homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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