Phenotypes associated with this allele

• Allele Symbol: Ghr^tm1Mwat
• Allele Name: targeted mutation 1, Michael J Waters
• Allele ID: MGI:3526104
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ghr^tm1Mwat/Ghr^tm1Mwat	involves: 129X1/SvJ * C57BL	MGI:3526381
ht2	Ghr^tm1Mwat/Ghr^+	involves: 129X1/SvJ * C57BL	MGI:3526385

Genotype
MGI:3526381

hm1

• Allelic Composition: Ghr^tm1Mwat/Ghr^tm1Mwat
• Genetic Background: involves: 129X1/SvJ * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:95149 )

• growth retardation becomes apparent after 3 weeks of age

• growth retardation is not as severe as in Ghr^tm2Mwat or Ghr^tm1Jjk homozygotes

homeostasis/metabolism

hyperglycemia ( J:95149 )

• 4 and 10 month old males but not females display fasting hyperglycemia

decreased circulating insulin-like growth factor I level ( J:95149 )

• serum levels of IGF1 are 16% - 21% of wild-type, a greater reduction than is expected from the decrease in liver transcript levels

nervous system

increased brain weight ( J:95149 )

• brain to body weight ratios are increased in mutants compared to wild-type mice

Genotype
MGI:3526385

ht2

• Allelic Composition: Ghr^tm1Mwat/Ghr⁺
• Genetic Background: involves: 129X1/SvJ * C57BL

growth/size/body

postnatal growth retardation ( J:95149 )

• growth retardation becomes apparent after 3 weeks of age