Analysis Tools
adipose tissue
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• in 4 and 10 month old males an increase in the relative weight of fat pad in all fat depots is seen
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growth/size/body
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• growth retardation becomes apparent after 3 weeks of age
• growth retardation is not as severe as in Ghrtm1Jjk homozygotes but more severe than in Ghrtm1Mwat homozygotes
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hematopoietic system
small spleen
(
J:95149
)
|
• a disproportionate decrease in spleen size compared to body size is seen
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homeostasis/metabolism
hyperglycemia
(
J:95149
)
|
• 4 and 10 month old males but not females display fasting hyperglycemia
|
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• serum levels of IGF1 are less than 10% of wild-type, a greater reduction than is expected from the decrease in liver transcript levels
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immune system
small spleen
(
J:95149
)
|
• a disproportionate decrease in spleen size compared to body size is seen
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liver/biliary system
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• a disproportionate decrease in liver weight compared to body weight is seen
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renal/urinary system
small kidney
(
J:95149
)
|
• a disproportionate decrease in kidney size compared to body size is seen
|
nervous system
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• brain to body weight ratios are increased in mutants compared to wild-type mice
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