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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fbxw8Gt(RRT057)Byg
gene trap RRT057, BayGenomics
MGI:3526146
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3812084


Genotype
MGI:3812084
hm1
Allelic
Composition
Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw8Gt(RRT057)Byg mutation (1 available); any Fbxw8 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• while 70% of mice die at birth some survive to weaning
• 70% of mice die at birth

growth/size/body
• at E12.5, mice are 83% of wild-type in size
• at 1 month of age, surviving mice are 70% of wild-type weight
• at E18.5, mice are 67% of wild-type in size

embryo
• at E12.5, mice are 83% of wild-type in size
• at mid-gestation, placental weight is 60% to 67% of wild-type

respiratory system
• following recovery at E18.5, alveolar space is reduced compared to in wild-type mice indicating a failure of lungs to inflate
• recovered E18.5 mice fail to initiate or sustain strong and regular breathing unlike wild-type mice

nervous system
• despite all other organs being proportionally reduced according to decreased body size, the brain is the same size as in wild-type mice

homeostasis/metabolism
• in mice recovered at E18.5

skeleton
N
• mice exhibit normal vertebral bodies and femurs





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory