mortality/aging
• while 70% of mice die at birth some survive to weaning
|
• 70% of mice die at birth
|
growth/size/body
• at E12.5, mice are 83% of wild-type in size
|
• at 1 month of age, surviving mice are 70% of wild-type weight
|
• at E18.5, mice are 67% of wild-type in size
|
embryo
• at E12.5, mice are 83% of wild-type in size
|
• at mid-gestation, placental weight is 60% to 67% of wild-type
|
respiratory system
atelectasis
(
J:130238
)
• following recovery at E18.5, alveolar space is reduced compared to in wild-type mice indicating a failure of lungs to inflate
|
• recovered E18.5 mice fail to initiate or sustain strong and regular breathing unlike wild-type mice
|
nervous system
• despite all other organs being proportionally reduced according to decreased body size, the brain is the same size as in wild-type mice
|
homeostasis/metabolism
skeleton
N |
• mice exhibit normal vertebral bodies and femurs
|