Phenotypes associated with this allele

• Allele Symbol: Hoxd1^tm1Mrc
• Allele Name: targeted mutation 1, Mario R Capecchi
• Allele ID: MGI:3526155
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd1^tm1Mrc/Hoxd1^tm1Mrc	involves: 129	MGI:4947861

Genotype
MGI:4947861

hm1

• Allelic Composition: Hoxd1^tm1Mrc/Hoxd1^tm1Mrc
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal skin sensory neuron innervation pattern ( J:170402 )

• mice exhibit abnormal nociceptor innervation of the skin compared with wild-type mice

• mice exhibit reduced peripherin+ axonal endings associated with hair follicles compared with wild-type mice

behavior/neurological

abnormal nociception after inflammation ( J:170402 )

• mice exhibit prolonged carrageenan-induced thermal allodynia compared with similarly treated wild-type mice

increased thermal nociceptive threshold ( J:170402 )

• mice exhibit longer latency to extremely cold surface compared with wild-type mice

nervous system

abnormal sensory neuron innervation pattern ( J:170402 )

• mice exhibit a large number of aberrant nociceptor axonal projections in the spinal cord compared with wild-type mice

abnormal skin sensory neuron innervation pattern ( J:170402 )

• mice exhibit abnormal nociceptor innervation of the skin compared with wild-type mice

• mice exhibit reduced peripherin+ axonal endings associated with hair follicles compared with wild-type mice