Phenotypes associated with this allele

• Allele Symbol: Mtrr^Gt(XG334)Byg
• Allele Name: gene trap XG334, BayGenomics
• Allele ID: MGI:3526159
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtrr^Gt(XG334)Byg/Mtrr^Gt(XG334)Byg	B6.129P2-Mtrr^Gt(XG334)Byg	MGI:3711342
hm2	Mtrr^Gt(XG334)Byg/Mtrr^Gt(XG334)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3711026

Genotype
MGI:3711342

hm1

• Allelic Composition: Mtrr^Gt(XG334)Byg/Mtrr^Gt(XG334)Byg
• Genetic Background: B6.129P2-Mtrr^Gt(XG334)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:121477 )

• liver AdoMet levels are increased (69.0+/-0.2uM compared to 38.0+/-4.3uM in wild-type)

abnormal circulating homocysteine level ( J:121477 )

• AdoHcy levels are increased in the heart (2.0+/-0.3 compared to 0.9+/-0.2 in wild-type) and in the liver in one trial but not another

• the AdoMet/AdoHcy ratio is increased in the liver (2.2+/-0.2 compared to 0.8+/-0.2 in wild-type) but decreased in the heart (18.4+/-1.4 compared to 46.9+/-7.2 in wild-type)

Genotype
MGI:3711026

hm2

• Allelic Composition: Mtrr^Gt(XG334)Byg/Mtrr^Gt(XG334)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

homeostasis/metabolism

abnormal amino acid level ( J:121477 )

• liver AdoMet levels are increased (64.1+/-6.43nmol/g compared to 45.9+/-4.53nmol/g in wild-type)

• liver AdoHcy levels are reduced (30.7+/-4.73nmol/g compared to 60.6+/-8.3nmol/g in wild-type)

• the AdoMet/AdoHcy ratio is increased in the liver (2.9+/-0.6 compared to 0.9+/-0.2 in wild-type)

increased circulating homocysteine level ( J:121477 )

• plasma homocysteine levels are increased (18.4+/-5.5uM compared to 4.6+/-0.8uM in wild-type)

• hyperhomocysteinemia similar to that seen in Mthfr^tm1Rzn homozygotes

decreased circulating methionine level ( J:121477 )

• plasma methionine levels are reduced (40.4+/-6.6uM compared to 59.4+/-7.4uM in wild-type)

growth/size/body

decreased body weight ( J:121477 )

• by 7 weeks, male mice (weighing on average 25.1g) are 10% smaller than wild-type (weighing 28.0g)

• however, female weight is normal