About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tex11tm1Jw
targeted mutation 1, Jeremy Wang
MGI:3526163
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tex11tm1Jw/Tex11tm1Jw
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3811495
cn2
 		Tex11tm1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3811496


Genotype
MGI:3811495
cn1
Allelic
Composition		 Tex11tm1Jw/Tex11tm1Jw
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex11tm1Jw mutation (0 available); any Tex11 mutation (21 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chiasmata formation ( J:131722 )
• pachytene oocytes contain asynapsed chromosomes unlike in wild-type mice

cellular
abnormal chiasmata formation ( J:131722 )
• pachytene oocytes contain asynapsed chromosomes unlike in wild-type mice




Genotype
MGI:3811496
cn2
Allelic
Composition		 Tex11tm1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex11tm1Jw mutation (0 available); any Tex11 mutation (21 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chiasmata formation ( J:131722 )
• some spermatocytes exhibit desynapsis at diplotene due to defective crossover formation during pachytene
meiotic nondisjunction during M1 phase ( J:131722 )
• during anaphase, a few chromatin masses migrate ahead or lag behind the two major chromatin masses unlike in wild-type spermatocytes
increased male germ cell apoptosis ( J:131722 )
• sperm cells undergo increased apoptosis compared to in wild-type mice during pachytene and anaphase I
decreased testis weight ( J:131722 )
• testes weight is 50% of wild-type

endocrine/exocrine glands
decreased testis weight ( J:131722 )
• testes weight is 50% of wild-type

cellular
abnormal chiasmata formation ( J:131722 )
• some spermatocytes exhibit desynapsis at diplotene due to defective crossover formation during pachytene
meiotic nondisjunction during M1 phase ( J:131722 )
• during anaphase, a few chromatin masses migrate ahead or lag behind the two major chromatin masses unlike in wild-type spermatocytes
increased male germ cell apoptosis ( J:131722 )
• sperm cells undergo increased apoptosis compared to in wild-type mice during pachytene and anaphase I




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory