All Phenotypes Nxf2<tm1.1Jw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nxf2^tm1.1Jw
targeted mutation 1.1, Jeremy Wang
MGI:3526168

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nxf2^tm1.1Jw Nxf3^tm1.1Jw/Y Tg(Ddx4-cre)1Dcas/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:5500935
cn2	Nxf2^tm1.1Jw Nxf3^tm1.1Jw/Y Tmem163^{Tg(ACTB-cre)2Mrt}/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5500932

Allelic Composition	Nxf2^tm1.1Jw Nxf3^tm1.1Jw/Y Tg(Ddx4-cre)1Dcas/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf2^tm1.1Jw mutation (1 available); any Nxf2 mutation (4 available)
Nxf3^tm1.1Jw mutation (1 available); any Nxf3 mutation (8 available)
Tg(Ddx4-cre)1Dcas mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

elongated sperm flagellum ( J:199138 )

oligozoospermia ( J:199138 )

• less than 8% of wild-type

globozoospermia ( J:199138 )

abnormal X-Y chromosome synapsis during male meiosis ( J:199138 )

small testis ( J:199138 )

decreased testis weight ( J:199138 )

arrest of spermatogenesis ( J:199138 )

• the most advanced germ cells are at the pachytene stage

arrest of male meiosis ( J:199138 )

male infertility ( J:199138 )

endocrine/exocrine glands