Phenotypes associated with this allele

• Allele Symbol: Dusp6^tm1Sms
• Allele Name: targeted mutation 1, Suzanne L Mansour
• Allele ID: MGI:3526178
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp6^tm1Sms/Dusp6^tm1Sms	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3697387
ht2	Dusp6^tm1Sms/Dusp6^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3697388

Genotype
MGI:3697387

hm1

• Allelic Composition: Dusp6^tm1Sms/Dusp6^tm1Sms
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:117073 )

• fewer than expected are found at weaning

• Background Sensitivity: with further crosses to C57BL/6 mice the number of mutants found at weaning decreases

growth/size/body

decreased body weight ( J:117073 )

• about 40% of P5 - P16 homozygotes have a body weight that is less than 75% of their littermate average

• however, mice with reduced body weight are not normally found at weaning

skeleton

abnormal cranium morphology ( J:117073 )

• at P10 the skull vault height to length and height to width ratios are increased in small mice only

abnormal middle ear ossicle morphology ( J:117073 )

• variable abnormalities of the middle ear bones in some small mice

abnormal long bone epiphyseal ossification zone morphology ( J:117073 )

• at P14 small mice have severely reduced ossification zones in the proximal tibia

abnormal long bone hypertrophic chondrocyte zone ( J:117073 )

• at P14 small mice have severely reduced hypertrophic zones with disorganized chondrocytes in the proximal tibia

premature coronal suture closure ( J:117073 )

• coronal craniosynostosis at P5-15 in small mice only

delayed bone ossification ( J:117073 )

• a slight delay in the ossification sequence of the phalanges is seen in small mice

• however, no obvious hand or foot malformations are seen

hearing/vestibular/ear

abnormal middle ear ossicle morphology ( J:117073 )

• variable abnormalities of the middle ear bones in some small mice

abnormal otic capsule morphology ( J:117073 )

• variable abnormalities of the otic capsule in some small mice

abnormal auditory brainstem response ( J:117073 )

• unilateral or bilateral elevation in auditory brainstem responses were seen in 1 of 2 small mice that survived to P21-28

craniofacial

abnormal cranium morphology ( J:117073 )

• at P10 the skull vault height to length and height to width ratios are increased in small mice only

abnormal middle ear ossicle morphology ( J:117073 )

• variable abnormalities of the middle ear bones in some small mice

Genotype
MGI:3697388

ht2

• Allelic Composition: Dusp6^tm1Sms/Dusp6⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

postnatal lethality ( J:117073 )

• fewer than expected are found at weaning

• Background Sensitivity: with further crosses to C57BL/6 mice the number of mutants found at weaning decreases

skeleton

abnormal cranium morphology ( J:117073 )

• at P10 the skull vault height to length and height to width ratios are increased in small mice only and not in small or normal sized wild-type mice

abnormal middle ear ossicle morphology ( J:117073 )

• variable abnormalities of the middle ear bones in some small mice

premature coronal suture closure ( J:117073 )

• coronal craniosynostosis at P5-15 in small mice only and not in small or normal sized wild-type mice

hearing/vestibular/ear

abnormal middle ear ossicle morphology ( J:117073 )

• variable abnormalities of the middle ear bones in some small mice

abnormal otic capsule morphology ( J:117073 )

• variable abnormalities of the otic capsule in some small mice

abnormal auditory brainstem response ( J:117073 )

• unilateral or bilateral elevation in auditory brainstem responses were seen in 3 of 3 small mice that survived to P21-28

craniofacial

abnormal cranium morphology ( J:117073 )

• at P10 the skull vault height to length and height to width ratios are increased in small mice only and not in small or normal sized wild-type mice

abnormal middle ear ossicle morphology ( J:117073 )

• variable abnormalities of the middle ear bones in some small mice