Analysis Tools
respiratory system
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• E17.5 embryos often have hemorrhaging in the lung
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• at E12, moderate increases in apoptosis are observed in the primary bronchi of both lungs
• cell death extended farther into the medial and accessory branches and there was a small area of ectopic death observed in the mesenchyme of either the vestigial rostral lobe or at the distal tip of the accessory lobe
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• all lobes exhibit reduced branching following outgrowth of the initial branch that established the lobe
• mesenchymal protrusions without an accompanying epithelial branch are occasionally observed during embryonic development
• such protrusions are observed only in the right lung in positions that correspond to lobes
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• at E17.5, mutant lobes are smaller and much flatter than control lobes
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• at E12.5, the accessory lobe is reduced in size and often misshapen
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• most E11.5 embryos have a reduction or absence of the nascent rostral lobe
• at E12.5, the rostral lobe is absent in the majority of mice
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• at E12.5, the medial lobe is reduced in size and often misshapen
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• at E17.5, mutant lobes are smaller than control lobes
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small lung
(
J:150706
)
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• at E12.5, mutant lungs are smaller than control lungs
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• at E17.5, mutant lungs are severely hypoplastic
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cardiovascular system
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• E17.5 embryos often have hemorrhaging in the lung
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