Phenotypes associated with this allele

• Allele Symbol: Zpr1^tm1Rjd
• Allele Name: targeted mutation 1, Roger J Davis
• Allele ID: MGI:3526216
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zpr1^tm1Rjd/Zpr1^tm1Rjd	involves: 129S6/SvEvTac * C57BL/6J	MGI:3576517

Genotype
MGI:3576517

hm1

• Allelic Composition: Zpr1^tm1Rjd/Zpr1^tm1Rjd
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:97582 )

• homozygous embryos die after E3.5 but before E9.5

embryo

abnormal inner cell mass apoptosis ( J:97582 )

• homozygous embryos display increased apoptosis in the inner cell mass

decreased inner cell mass proliferation ( J:97582 )

• homozygous embryos display decreased cell proliferation in the inner cell mass

abnormal inner cell mass morphology ( J:97582 )

• homozygous embryos fail to expand the inner cell mass

• mutant embryonic cells have a smooth surface lacking microvilli and lack Cajal bodies seen in wild-type cells

abnormal trophectoderm morphology ( J:97582 )

• homozygous embryos form a thin, irregular trophectoderm

abnormal trophoblast giant cell morphology ( J:97582 )

• homozygous embryos display decreased endoreduplication of the trophoblast giant cells

cellular

abnormal Cajal body morphology ( J:97582 )

• mutant embryonic cells lack Cajal bodies

abnormal inner cell mass apoptosis ( J:97582 )

• homozygous embryos display increased apoptosis in the inner cell mass

decreased inner cell mass proliferation ( J:97582 )

• homozygous embryos display decreased cell proliferation in the inner cell mass