Phenotypes associated with this allele

• Allele Symbol: Glrx^tm1Ysh
• Allele Name: targeted mutation 1, Ye-Shih Ho
• Allele ID: MGI:3526399
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glrx^tm1Ysh/Glrx^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ	MGI:3759312

Genotype
MGI:3759312

hm1

• Allelic Composition: Glrx^tm1Ysh/Glrx^tm1Ysh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased sensitivity to induced cell death ( J:125192 )

• mouse embryonic fibroblast cells are more resistant than wild-type cells to apoptosis induced by tumor necrosis factor alpha plus actinomycin D

increased cellular sensitivity to oxidative stress ( J:125192 )

• mouse embryonic fibroblast cells are more sensitive to cell damage caused by diquat and paraquat than by peroxide and diamide compared to wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:125192 )

N • mice respond to myocardial injury after ischemia/reperfusion insult in the same way as wild-type mice

respiratory system

respiratory system phenotype ( J:125192 )

N • mice respond to hypoxia-induced lung injury in the same way as wild-type mice