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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zap70st
strange
MGI:3526403
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zap70st/Zap70st involves: C57BL/6 MGI:3526699
ht2
 		Zap70st/Zap70tm1Dlo involves: C57BL/6 MGI:3526700


Genotype
MGI:3526699
hm1
Allelic
Composition		 Zap70st/Zap70st
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70st mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage
decreased T cell number ( J:41170 )
• no single positive T cells are seen in spleen and lymph nodes
abnormal T cell physiology ( J:41170 )
• antibody induced co-cross-linking of surface T cell receptors and CD4 failed to mobilize intracellular calcium in mutant T cells unlike in wild-type cells

immune system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage
decreased T cell number ( J:41170 )
• no single positive T cells are seen in spleen and lymph nodes
abnormal T cell physiology ( J:41170 )
• antibody induced co-cross-linking of surface T cell receptors and CD4 failed to mobilize intracellular calcium in mutant T cells unlike in wild-type cells

endocrine/exocrine glands




Genotype
MGI:3526700
ht2
Allelic
Composition		 Zap70st/Zap70tm1Dlo
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70st mutation (0 available); any Zap70 mutation (55 available)
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage

immune system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory