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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zap70st
strange
MGI:3526403
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zap70st/Zap70st involves: C57BL/6 MGI:3526699
ht2
Zap70st/Zap70tm1Dlo involves: C57BL/6 MGI:3526700


Genotype
MGI:3526699
hm1
Allelic
Composition
Zap70st/Zap70st
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70st mutation (0 available); any Zap70 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocytes fail to mature beyond the double positive stage
• no single positive T cells are seen in spleen and lymph nodes
• antibody induced co-cross-linking of surface T cell receptors and CD4 failed to mobilize intracellular calcium in mutant T cells unlike in wild-type cells

immune system
• thymocytes fail to mature beyond the double positive stage
• no single positive T cells are seen in spleen and lymph nodes
• antibody induced co-cross-linking of surface T cell receptors and CD4 failed to mobilize intracellular calcium in mutant T cells unlike in wild-type cells

endocrine/exocrine glands




Genotype
MGI:3526700
ht2
Allelic
Composition
Zap70st/Zap70tm1Dlo
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70st mutation (0 available); any Zap70 mutation (55 available)
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocytes fail to mature beyond the double positive stage

immune system
• thymocytes fail to mature beyond the double positive stage





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory