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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stx2tm1Dcru
targeted mutation 1, Deborah C Rubin
MGI:3526405
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stx2tm1Dcru/Stx2tm1Dcru involves: 129X1/SvJ MGI:5445567
hm2
 		Stx2tm1Dcru/Stx2tm1Dcru involves: 129X1/SvJ * C57BL/6J MGI:3640503
ht3
 		Stx2tm1Dcru/Stx2+ involves: 129X1/SvJ * C57BL/6J MGI:3640507
cn4
 		Stx2tm1Dcru/Stx2tm1Dcru
Stx4atm2Jpes/Stx4atm2Jpes
Tg(Pf4-icre)Q3Rsko/0 		involves: 129X1/SvJ * C57BL/6 MGI:5445566


Genotype
MGI:5445567
hm1
Allelic
Composition		 Stx2tm1Dcru/Stx2tm1Dcru
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx2tm1Dcru mutation (1 available); any Stx2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:189176 )
N
• platelets exhibit normal exocytosis




Genotype
MGI:3640503
hm2
Allelic
Composition		 Stx2tm1Dcru/Stx2tm1Dcru
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx2tm1Dcru mutation (1 available); any Stx2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:110376 )
• at 3 months increased numbers of apoptotic germ cells with darkly stained condensed nuclei are seen in many seminiferous tubules
abnormal seminiferous tubule morphology ( J:110376 )
• meitotic germ cells are found in clusters detached from the basal lamina
decreased testis weight ( J:110376 )
• at 3 weeks and 4 months of age testes weigh 20% and 50% less than wild-type
abnormal spermatogenesis ( J:110376 )
• by 4 months of age profound germ cell degeneration is seen, spermatids are depleted and spermatozoa are absent
• increased numbers of apoptotic germ cells
• however, spermatogonia and spermatocytes are present and proliferation of spermatogonia appears normal
decreased litter size ( J:110376 )
• females produce smaller litters but no genotype dependent loss of pups is seen and females are able to nurse their pups

cellular
increased male germ cell apoptosis ( J:110376 )
• at 3 months increased numbers of apoptotic germ cells with darkly stained condensed nuclei are seen in many seminiferous tubules
abnormal small intestinal crypt cell proliferation ( J:110376 )
• at 3 weeks of age crypt cell proliferation is increased in the small intestine

digestive/alimentary system
abnormal small intestinal crypt cell proliferation ( J:110376 )
• at 3 weeks of age crypt cell proliferation is increased in the small intestine
abnormal small intestine crypts of Lieberkuhn morphology ( J:110376 )
• at 3 weeks of age crypt depth, crypt cell proliferation, and the percentage of duplicated crypts are increased in the small intestine
increased colon length ( J:110376 )
• increased length at 4 months of age
abnormal small intestinal villus morphology ( J:110376 )
• at 3 weeks of age villus length is increased
branched small intestinal villi ( J:110376 )
• at 3 weeks and 3 months of age scattered foci of abnormal villus branching are present
increased small intestine length ( J:110376 )
• at 4 months but not 3 weeks small intestine length is increased
decreased susceptibility to induced colitis ( J:110376 )
• reduced severity of dextran sodium sulfate induced chemical colitis

immune system
decreased susceptibility to induced colitis ( J:110376 )
• reduced severity of dextran sodium sulfate induced chemical colitis

liver/biliary system
increased liver weight ( J:110376 )
• at 4 months of age

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:110376 )
• at 3 weeks of age crypt depth, crypt cell proliferation, and the percentage of duplicated crypts are increased in the small intestine
abnormal seminiferous tubule morphology ( J:110376 )
• meitotic germ cells are found in clusters detached from the basal lamina
decreased testis weight ( J:110376 )
• at 3 weeks and 4 months of age testes weigh 20% and 50% less than wild-type

growth/size/body
increased liver weight ( J:110376 )
• at 4 months of age




Genotype
MGI:3640507
ht3
Allelic
Composition		 Stx2tm1Dcru/Stx2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx2tm1Dcru mutation (1 available); any Stx2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestinal crypt cell proliferation ( J:110376 )
• crypt cell proliferation is increased
abnormal small intestinal villus morphology ( J:110376 )
• villus length is increased

endocrine/exocrine glands

cellular
abnormal small intestinal crypt cell proliferation ( J:110376 )
• crypt cell proliferation is increased




Genotype
MGI:5445566
cn4
Allelic
Composition		 Stx2tm1Dcru/Stx2tm1Dcru
Stx4atm2Jpes/Stx4atm2Jpes
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx2tm1Dcru mutation (1 available); any Stx2 mutation (24 available)
Stx4atm2Jpes mutation (0 available); any Stx4a mutation (22 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:189176 )
N
• platelets exhibit normal exocytosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory