Phenotypes associated with this allele

• Allele Symbol: Etnk2^tm1Mkar
• Allele Name: targeted mutation 1, Suzanne Jackowski
• Allele ID: MGI:3526407
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etnk2^tm1Mkar/Etnk2^tm1Mkar	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3697477

Genotype
MGI:3697477

hm1

• Allelic Composition: Etnk2^tm1Mkar/Etnk2^tm1Mkar
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

maternal effect ( J:117170 )

• homozygous females mated with homozygous males or wild-type males give birth to smaller litters, with a mixture of average size pups and low birth weight pups, which often die within 1 week of birth as well as some late gestation lethality; small litter size and pup mortality are not observed when homozygous males are mated with wild-type females or when heterozygotes are mated together

• fetal development fails at the late stage of pregnancy in homozygous females because of extensive placental thrombosis

reproductive system

reproductive system phenotype ( J:117170 )

N • testis appears normal

decreased litter size ( J:117170 )

• 33% reduction in litter size that is maternal-specific as matings of homozygous males with wild-type females results in normal litter sizes while matings of homozygous females with wild-type males results in low numbers of heterozygous offspring

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:117170 )

N • no difference in the phospholipid composition of the liver and homozygotes are capable of adapting to a choline-deficient diet

nervous system

nervous system phenotype ( J:117170 )

N • brain appears normal and mice do not appear to have overt neurological defects