Phenotypes associated with this allele

• Allele Symbol: Tmprss2^tm1Psn
• Allele Name: targeted mutation 1, Peter Nelson
• Allele ID: MGI:3526414
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmprss2^tm1Psn/Tmprss2^tm1Psn	B6JRj.129S1-Tmprss2^tm1Psn	MGI:6416808
hm2	Tmprss2^tm1Psn/Tmprss2^tm1Psn	involves: 129S1/Sv * 129X1/SvJ	MGI:3618284
hm3	Tmprss2^tm1Psn/Tmprss2^tm1Psn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6449257
cx4	Tg(TRAMP)8247Ng/0 Tmprss2^tm1Psn/Tmprss2^tm1Psn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6449260

Genotype
MGI:6416808

hm1

• Allelic Composition: Tmprss2^tm1Psn/Tmprss2^tm1Psn
• Genetic Background: B6JRj.129S1-Tmprss2^tm1Psn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to Orthomyxoviridae infection ( J:287633 )

• mice infected with influenza strain H10-HA did not lose body weight and no viral replication was observed in contrast to control mice

• mice infected with influenza strain H10-HA exhibited reduced inflammatory lesions with only mild or no damage of bronchial epithelium compared to controls

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:287633 )

• mice infected with influenza strain H10-HA did not exhibit lethality compared to 7 dpi mortality in control mice

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:287633 )

• mice infected with influenza strain H10-HA did not exhibit lethality compared to 7 dpi mortality in control mice

Genotype
MGI:3618284

hm2

• Allelic Composition: Tmprss2^tm1Psn/Tmprss2^tm1Psn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

normal phenotype

no abnormal phenotype detected ( J:105558 )

• homozygotes develop normally, are viable and fertile, and do not exhibit any abnormalities in the prostate, kidneys, stomach, small intestine, colon, pancreas, testes, lungs, liver, ovaries, and uterus, or in prostatic and seminal vesicle protein secretions or in the regeneration of prostate epithelium following castration and testosterone replacement

Genotype
MGI:6449257

hm3

• Allelic Composition: Tmprss2^tm1Psn/Tmprss2^tm1Psn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

immune system

decreased susceptibility to Orthomyxoviridae infection ( J:244166 )

• mice show decreased susceptibility to intranasal infection with H1N1 influenza viruses, including the mouse adapted PR8M (A/PuertoRico/8/34 H1N1 Munster variant), a human isolate of the pandemic HA4 (A/Hamburg/4/2009 H1N1) virus, or the more virulent PR8F virus isolate (A/PuertoRico/8/34 H1N1 Freiburg variant), showing no weight loss or signs of disease

• H1N1 influenza-infected mice show a much lower number of infiltrating cells into the lungs and reduced virus spread, and readily detectable influenza-specific antibodies

• mice show protection from intranasal infection with the mouse-adapted H3N2 influenza virus (A/HK/01/68) but to a lesser extent than what is seen with the H1N1 influenza virus, showing less severe body weight loss and increased survival

• however, mice show a similar susceptibility to infection with SC35M, a mouse-adapted A/Seal/Massachusetts/1/80, H7N7, influenza virus as wild-type mice

Genotype
MGI:6449260

cx4

• Allelic Composition: Tg(TRAMP)8247Ng/0; Tmprss2^tm1Psn/Tmprss2^tm1Psn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

neoplasm

decreased metastatic potential ( J:217920 )

♂ • the incidence of metastasis to distant solid organs is lower, with only 7% of mice having gross metastasis to solid organs compared to 61% of controls

♂ • primary tumors derived from mutant mice fail to generate metastasis in wild-type recipient mice

♂ • primary tumor cells from mutant donor mice injected into the tibia of recipient hosts results in no tumor development unlike controls that show tumors in the bone

increased tumor growth/size ( J:217920 )

♂ • mice develop prostate tumors that are more than twice as large as in controls