Phenotypes associated with this allele

• Allele Symbol: Nherf1^tm1Geo
• Allele Name: targeted mutation 1, Maria-Magdelena Georgescu
• Allele ID: MGI:3526430
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nherf1^tm1Geo/Nherf1^tm1Geo	involves: C57BL/6J	MGI:3526870

Genotype
MGI:3526870

hm1

• Allelic Composition: Nherf1^tm1Geo/Nherf1^tm1Geo
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:95282 )

• only rarely do females develop progressive weakness and die

digestive/alimentary system

abnormal intestine morphology ( J:95282 )

• the intestines are more fragile than wild-type

abnormal intestinal goblet cell morphology ( J:95282 )

• 2 times as many goblet cells are found in the villi and crypts

abnormal intestinal epithelium morphology ( J:95282 )

• the apical brush border of intestinal epithelial cells contain disorganized microvilli and dispersed actin-rich terminal webs

homeostasis/metabolism

decreased circulating phosphate level ( J:95282 )

• phosphate levels are 6.3 mg/dl compared to 7.4 mg/dl in wild-type mice

cellular

abnormal intestinal goblet cell morphology ( J:95282 )

• 2 times as many goblet cells are found in the villi and crypts