All Phenotypes Wnt9b<tm1.1Amc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt9b^tm1.1Amc
targeted mutation 1.1, Andrew P McMahon
MGI:3526437

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129/Sv * 129X1/SvJ * C57BL/6J	MGI:3848509
hm2	Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3589874
hm3	Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6J * NMRI	MGI:3845626
ht4	Wnt9b^tm1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3589875
cn5	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Tg(Hoxb7-cre)13Amc/0 Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3716215
cn6	Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:5428000
cn7	Ctnnb1^tm1Mmt/Ctnnb1⁺ Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc Tg(Cdh16-cre)91Igr/0	involves: 129X1/SvJ * ICR	MGI:5428001
cn8	Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc Tg(Cdh16-cre)91Igr/0	involves: 129X1/SvJ * ICR	MGI:5427999
cx9	Six2^tm1Gco/Six2^tm1Gco Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129/Sv * 129X1/SvJ * C57BL/6J	MGI:3848508
cx10	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3716214
cx11	Six2^tm1Gco/Six2^tm1Gco Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc	involves: 129X1/SvJ * C57BL/6J * NMRI	MGI:3845624

Allelic Composition	Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:148455 )

• at 12.5 dpc, the amount of cap mesenchyme is reduced compared to controls

delayed kidney development ( J:148455 )

• no renal vesicle formation is observed at 12.5 dpc

Allelic Composition	Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:100575 )

renal/urinary system

abnormal kidney collecting duct morphology ( J:100575 )

abnormal kidney development ( J:100575 )

• at birth only vestigial kidneys are present

• mesenchymally derived tubular epithelia is absent

abnormal ureteric bud morphology ( J:100575 )

impaired branching involved in ureteric bud morphogenesis ( J:100575 )

• ureteric bud invasion into the mesenchyme and initial branching is normal; however, branching after the T-stage is disrupted

reproductive system

oviduct hypoplasia ( J:100575 )

• most of the oviduct is absent at birth

absent uterus ( J:100575 )

absent cranial vagina ( J:100575 )

• the upper vagina is absent at birth

absent epididymis ( J:100575 )

absent vas deferens ( J:100575 )

craniofacial

cleft upper lip ( J:100575 )

• incomplete penetrance

cleft palate ( J:100575 )

• incomplete penetrance

digestive/alimentary system

cleft palate ( J:100575 )

• incomplete penetrance

embryo

abnormal Mullerian duct morphology ( J:100575 )

• posterior extension of the Mullerian duct fails to occur

absent Wolffian ducts ( J:100575 )

• at E11.5, no histologically detectable mesonephric tubules are observed

growth/size/body

cleft upper lip ( J:100575 )

• incomplete penetrance

cleft palate ( J:100575 )

• incomplete penetrance

Allelic Composition	Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129X1/SvJ * C57BL/6J * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:148455 )

• no renal vesicle formation is observed at 12.5 dpc

• reduction of Pax2+ve cap mesenchyme is observed at 12.5 dpc

Allelic Composition	Wnt9b^tm1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)
Wnt9b^tm1Amc mutation (0 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

small kidney ( J:100575 )

• small kidneys with few mature nephrons are seen

Allelic Composition	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Tg(Hoxb7-cre)13Amc/0 Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:100575 )

N	• when the Wnt1:GFP fusion protein is expressed in the Wolffian duct, embryos exhibit normal mesonephric and metanephric tubule induction, as well as caudal extension of the Mullerian duct

Allelic Composition	Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)
Wnt9b^tm1.2Amc mutation (1 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:151498 )

• all mice treated with tamoxifen from E15.5 die by P90

renal/urinary system

kidney cyst ( J:151498 )

• in mice treated with tamoxifen from E15.5 to P10

• however, mice treated with tamoxifen after P10 do not develop cysts

growth/size/body

kidney cyst ( J:151498 )

• in mice treated with tamoxifen from E15.5 to P10

• however, mice treated with tamoxifen after P10 do not develop cysts

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc Tg(Cdh16-cre)91Igr/0
Genetic Background	involves: 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)
Wnt9b^tm1.2Amc mutation (1 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney cyst ( J:151498 )

• cystic index at P1 is increased compared to in Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc Tg(Cdh16-cre)91Igr mice

growth/size/body

kidney cyst ( J:151498 )

• cystic index at P1 is increased compared to in Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc Tg(Cdh16-cre)91Igr mice

Allelic Composition	Wnt9b^tm1.1Amc/Wnt9b^tm1.2Amc Tg(Cdh16-cre)91Igr/0
Genetic Background	involves: 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cdh16-cre)91Igr mutation (1 available)
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)
Wnt9b^tm1.2Amc mutation (1 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:151498 )

• most mice die between P30 and P45 with no mice surviving past P60

renal/urinary system

kidney cyst ( J:151498 )

• delayed compared to in Wnt9b^tm1Amc homozygotes

• few cysts at P1

• prevalent by P10

• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct

renal glomerulus cyst ( J:151498 )

abnormal kidney collecting duct epithelium morphology ( J:151498 )

• collecting duct epithelial cells exhibit randomized elongation unlike in wild-type mice

abnormal renal tubule epithelium morphology ( J:151498 )

• at P5, epithelium cell divisions are not oriented within the plane of the epithelium unlike in control mice

• by P30, little normal epithelia remains

dilated renal tubule ( J:151498 )

growth/size/body

kidney cyst ( J:151498 )

• delayed compared to in Wnt9b^tm1Amc homozygotes

• few cysts at P1

• prevalent by P10

• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct

renal glomerulus cyst ( J:151498 )

Allelic Composition	Six2^tm1Gco/Six2^tm1Gco Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six2^tm1Gco mutation (0 available); any Six2 mutation (16 available)
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:148455 )

• at 12.5 dpc, the amount of cap mesenchyme is greatly reduced

delayed kidney development ( J:148455 )

• no renal vesicle formation is observed at 12.5 dpc

• ingrowth of the ureteric bud is delayed compared to controls at 11.5 dpc

Allelic Composition	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Wnt9b^tm1.1Amc mutation (0 available); any Wnt9b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:100575 )

• phenotype is stated to be identical to that of Wnt9b^tm1.1Amc homozygotes; however only limited data is presented

renal/urinary system

abnormal kidney collecting duct morphology ( J:100575 )

abnormal kidney development ( J:100575 )

• no pretubular aggregates are apparent

embryo

abnormal Mullerian duct morphology ( J:100575 )

• development is arrested

Allelic Composition	Six2^tm1Gco/Six2^tm1Gco Wnt9b^tm1.1Amc/Wnt9b^tm1.1Amc
Genetic Background	involves: 129X1/SvJ * C57BL/6J * NMRI

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:148455 )

• no renal vesicle formation is observed at 12.5 dpc

• ingrowth of the ureteric bud is delayed compared to Six2- or Wnt9b-null animals

• significant reduction of Pax2+ve cap mesenchyme is observed at 12.5 dpc; reduction is more severe than in Wnt9b single null mice

• renal vesicle-forming progenitors are depleted in the cap mesenchyme

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24