Analysis Tools
growth/size/body
 |
• body weights of hemizygous males are about 80% of wild-type littermates at birth
|
|
|
• mild growth retardation persists through the entire life span
|
hematopoietic system
|
|
• splenocyte proliferation in response to LPS is reduced compared to wild-type
|
|
|
• significant thymic atrophy is seen with mutant thymi weighing about half as much as wild-type
|
|
|
• a slight decrease in red blood cell count is seen in mutants at 6 and 13 weeks of age
|
|
|
• in 6 week old mutants, white blood cell count is reduced to 42% of wild-type
|
|
|
• in 6 week old mutants, the number of B220+ B lymphocytes is reduced to 33.3% of wild-type
|
|
|
• in 6 week old mutants, the number of CD3+ T lymphocytes is reduced to 44.8% of wild-type
|
|
|
• in 32-33 day old mutants, the number of thymocytes is reduced to about 20% of that in wild-type and the remaining thymocytes appear larger than wild-type cells
• thymocyte progression through S phase is delayed and more thymocytes are arrested in G2/M phase compared to wild-type cells
|
immune system
|
|
• splenocyte proliferation in response to LPS is reduced compared to wild-type
|
|
|
• significant thymic atrophy is seen with mutant thymi weighing about half as much as wild-type
|
|
|
• in 6 week old mutants, white blood cell count is reduced to 42% of wild-type
|
|
|
• in 6 week old mutants, the number of B220+ B lymphocytes is reduced to 33.3% of wild-type
|
|
|
• in 6 week old mutants, the number of CD3+ T lymphocytes is reduced to 44.8% of wild-type
|
|
|
• in 32-33 day old mutants, the number of thymocytes is reduced to about 20% of that in wild-type and the remaining thymocytes appear larger than wild-type cells
• thymocyte progression through S phase is delayed and more thymocytes are arrested in G2/M phase compared to wild-type cells
|
cellular
|
|
• thymocytes but not MEFS from mutant males are more sensitive cell death induced by x-ray irradiation
|
|
|
• splenocyte proliferation in response to LPS is reduced compared to wild-type
|
endocrine/exocrine glands
|
|
• significant thymic atrophy is seen with mutant thymi weighing about half as much as wild-type
|
|
|
• in 32-33 day old mutants, the number of thymocytes is reduced to about 20% of that in wild-type and the remaining thymocytes appear larger than wild-type cells
• thymocyte progression through S phase is delayed and more thymocytes are arrested in G2/M phase compared to wild-type cells
|
