Phenotypes associated with this allele

• Allele Symbol: Fstl3^tm1Alsc
• Allele Name: targeted mutation 1, Alan Schneyer
• Allele ID: MGI:3526450
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fstl3^tm1Alsc/Fstl3^tm1Alsc	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:3702940

Genotype
MGI:3702940

hm1

• Allelic Composition: Fstl3^tm1Alsc/Fstl3^tm1Alsc
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased pancreatic islet size in Fstl3^tm1Alsc/Fstl3^tm1Alsc mice

cardiovascular system

increased heart weight ( J:119526 )

• heart weight relative to body weight is increased in mutants

increased left ventricle systolic pressure ( J:119526 )

• left ventricular end systolic pressure is significantly increased compared to wild-type

hypertension ( J:119526 )

• mutants are hypertensive compared to wild-type

increased systemic arterial systolic blood pressure ( J:119526 )

• systolic arteriolar pressure is significantly increased compared to wild-type

growth/size/body

increased heart weight ( J:119526 )

• heart weight relative to body weight is increased in mutants

homeostasis/metabolism

increased circulating insulin level ( J:119526 )

• at 9 months, serum insulin is elevated in mutants

abnormal enzyme/coenzyme level ( J:119526 )

• expression of PEPCK and G6Pase is elevated 6- and 4.5-fold in mutant livers

improved glucose tolerance ( J:119526 )

• mice show enhanced glucose tolerance relative to wild-type littermates

decreased liver glycogen level ( J:119526 )

• liver glycogen content is substantially reduced in mutants

increased insulin sensitivity ( J:119526 )

• insulin sensitivity is enhanced relative to wild-type

liver/biliary system

liver/biliary system phenotype ( J:119526 )

N • liver function overall is not compromised compared to wild-type; fatty acid and triglyceride concentrations are normal, as are amino aspartate and amino alanine transferase enzymes

decreased liver glycogen level ( J:119526 )

• liver glycogen content is substantially reduced in mutants

hepatic steatosis ( J:119526 )

• liver steatosis is detected in 5 month old mutants but not in wild-type; steatosis increases in severity by 9 months

macrovesicular hepatic steatosis ( J:119526 )

• extensive

microvesicular hepatic steatosis ( J:119526 )

• extensive

adipose tissue

abnormal adipose tissue distribution ( J:119526 )

• fat distribution is preferentially shifted from visceral to subcutaneous depots and/or other organs

abnormal abdominal fat pad morphology ( J:119526 )

• male and female mutants have much smaller abdominal visceral fat deposits relative to wild-type, although fraction of body weight made up of fat is not different from wild-type

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:119526 )

• few alpha cells are found in the periphery of islets in mutants

• islets have more intra-islet capillaries

abnormal pancreatic beta cell morphology ( J:119526 )

• increase in islet size is likely due to beta cell hyperplasia

increased pancreatic beta cell number ( J:119526 )

• islets have larger number of insulin expressing beta cells than wild-type islets

enlarged pancreatic islets ( J:119526 )

• mice show increased pancreatic islet size; mean islet size is ~50% larger than wild-type

• distribution of islet sizes is different in mutants than in wild-type