Phenotypes associated with this allele

• Allele Symbol: Spred1^tm1Hiin
• Allele Name: targeted mutation 1, Hiromasa Inoue
• Allele ID: MGI:3526452
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spred1^tm1Hiin/Spred1^tm1Hiin	B6.Cg-Spred1^tm1Hiin	MGI:3836813
hm2	Spred1^tm1Hiin/Spred1^tm1Hiin	involves: C57BL/6	MGI:3526849

Genotype
MGI:3836813

hm1

• Allelic Composition: Spred1^tm1Hiin/Spred1^tm1Hiin
• Genetic Background: B6.Cg-Spred1^tm1Hiin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:144031 )

N • despite abnormal CNS transmission, mice exhibit normal dendritic arborization

abnormal excitatory postsynaptic potential ( J:144031 )

• the slope of field excitatory postsynaptic potentials is decreased compared to in wild-type mice

reduced long-term potentiation ( J:144031 )

• following a single theta burst stimulation

absent long-term depression ( J:144031 )

• following a train of low-frequency stimulation

enhanced paired-pulse facilitation ( J:144031 )

• at 10 and 20 ms interpulse intervals

behavior/neurological

abnormal discrimination learning ( J:144031 )

• in a T-maze, mice exhibit reduced visual discrimination compared to wild-type mice

abnormal spatial learning ( J:144031 )

• in a hidden-platform Morris water maze assay, mice perform worse than wild-type mice in the second week

• however, motivation and sensory-motor abilities are normal

abnormal spatial working memory ( J:144031 )

• mice spend less time in the target quadrant than wild-type mice in a Morris water maze when the platform is removed

increased thigmotaxis ( J:144031 )

impaired swimming ( J:144031 )

• mice swim slower and float more than wild-type mice

Genotype
MGI:3526849

hm2

• Allelic Composition: Spred1^tm1Hiin/Spred1^tm1Hiin
• Genetic Background: involves: C57BL/6

craniofacial

short face ( J:95263 )

• mutants have a shortened face

growth/size/body

short face ( J:95263 )

• mutants have a shortened face

decreased body weight ( J:95263 )

hematopoietic system

increased eosinophil cell number ( J:95263 )

• increased eosinophilia is seen in the airways of mutants during OVA-induced asthma

• injection of IL-5 induced a greater and longer lasting increase in peripheral eosinophil counts

abnormal eosinophil physiology ( J:95263 )

• eosinophil chemotaxis towards eotaxin is increased

immune system

increased eosinophil cell number ( J:95263 )

• increased eosinophilia is seen in the airways of mutants during OVA-induced asthma

• injection of IL-5 induced a greater and longer lasting increase in peripheral eosinophil counts

abnormal eosinophil physiology ( J:95263 )

• eosinophil chemotaxis towards eotaxin is increased

abnormal cytokine secretion ( J:95263 )

• after challenge with OVA the concentrations of IL-13 and eotaxin are increased

limbs/digits/tail

kinked tail ( J:95263 )

respiratory system

increased airway responsiveness ( J:95263 )

• in an induced asthma model mutants display enhanced airway responsiveness