All Phenotypes Homer2<tm1Mhd> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Homer2^tm1Mhd
targeted mutation 1, Marlin H Dehoff
MGI:3526530

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Homer2^tm1Mhd/Homer2^tm1Mhd	B6.129-Homer2^tm1Mhd	MGI:3716979
hm2	Homer2^tm1Mhd/Homer2^tm1Mhd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3526582
cx3	Homer2^tm1Mhd/Homer2^tm1Mhd Homer3^tm1Mhd/Homer3^tm1Mhd	involves: 129S1/Sv * 129X1/SvJ	MGI:5461825

Allelic Composition	Homer2^tm1Mhd/Homer2^tm1Mhd
Genetic Background	B6.129-Homer2^tm1Mhd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Homer2^tm1Mhd mutation (1 available); any Homer2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:96554 )

enhanced behavioral response to cocaine ( J:96554 )

• capacity of acute cocaine to elicit locomotor hyperactivity is enhanced in mutants compared to controls

abnormal cocaine consumption ( J:96554 )

• mutants acquire operant self-administration of cocaine more readily than controls

abnormal associative learning ( J:96554 )

• mutants exhibit cocaine-induced place conditioning compared to wild-type controls

• mice exhibit cocaine-induced place conditioning (increased time spent in environment containing stimulus/reward) at doses that do not elicit place conditioning in controls

• mutants acquire operant self-administration of cocaine more readily than controls

enhanced conditioned place preference behavior ( J:96554 )

• mice prefer to spend more time in chamber where cocaine is available compared to controls

nervous system

abnormal nervous system physiology ( J:96554 )

• mutants show lower (~50%) extracellular glutamate levels in the nucleus accumbens compared to wild-type mice; injection of cocaine into the nucleus accumbens causes elevation of extracellular glutamate levels in mutants but not wild-type controls

Allelic Composition	Homer2^tm1Mhd/Homer2^tm1Mhd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Homer2^tm1Mhd mutation (1 available); any Homer2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas physiology ( J:95213 )

• carbachol stimulated acinar cells showed a higher increase in intracellular calcium concentration due to increased calcium release from internal stores than controls

• two-fold increased frequency of intracellular calcium oscillations in acinar cells in response to stimulation with bombesin or CCK compared to controls

Allelic Composition	Homer2^tm1Mhd/Homer2^tm1Mhd Homer3^tm1Mhd/Homer3^tm1Mhd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Homer2^tm1Mhd mutation (1 available); any Homer2 mutation (22 available)
Homer3^tm1Mhd mutation (1 available); any Homer3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:191366 )

• formalin-treated mice exhibit greater response to pain during the second phase, but not the first phase, compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24