Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hoxc11tm1Mrc targeted mutation 1, Mario R Capecchi MGI:3526571 |
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| Summary |
13 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite altered vertebral identity, the number of vertebrae is normal
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• sacral vertebrae adopt lumbar vertebra morphologies
(J:84456)
• the sacral region is lumbar-like
(J:124112)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• anterior sacral vertebrae lack sacral wings unlike in wild-type mice
• however, posterior sacral elements possess sacral wings
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show reproductive defects similar to those of mice homozygous for Hoxa11tm1Mrc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show reproductive defects similar to those of mice homozygous for Hoxa11tm1Mrc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme
• absence of metanephric kidney development at E13.5 and birth
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• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme
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• absence of metanephric kidney development at E13.5 and birth
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• absence of bud formation at E11.5
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• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme
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• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• bilateral kidney hypoplasia that is less severe than in Hoxa11tm1Mrc Hoxd11tm1Mrc double homozygotes
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• occasionally seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypoplasia is more severe than in mice with 4 mutant alleles
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• kidneys, when present, are in a more caudal and ventral location
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• occasionally seen
• more frequent than in mice with 4 mutant alleles
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• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypoplasia is more severe than in mice with 4 mutant alleles
|
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• kidneys, when present, are in a more caudal and ventral location
|
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• occasionally seen
• more frequent than in mice with 4 mutant alleles
|
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• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• hypoplasia is more severe than in mice with 4 mutant alleles
|
|
• kidneys, when present, are in a more caudal and ventral location
|
|
• occasionally seen
• more frequent than in mice with 4 mutant alleles
|
|
• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• show reproductive defects similar to those of mice homozygous for Hoxa11tm1Mrc
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• show reproductive defects similar to those of mice homozygous for Hoxa11tm1Mrc
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• bilateral kidney hypoplasia that is less severe than in Hoxa11tm1Mrc Hoxd11tm1Mrc double homozygotes
|
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• occasionally seen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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