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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gzmatm1Ley
targeted mutation 1, Timothy J Ley
MGI:3526655
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gzmatm1Ley/Gzmatm1Ley involves: 129X1/SvJ MGI:4354613
hm2
 		Gzmatm1Ley/Gzmatm1Ley involves: 129X1/SvJ * C57BL/6 MGI:3526728
cx3
 		Gzmatm1Ley/Gzmatm1Ley
Gzmbtm1Ley/Gzmbtm1Ley 		involves: 129X1/SvJ MGI:4354615
cx4
 		Gzmatm1Ley/Gzmatm1Ley
Gzmbtm2.1Ley/Gzmbtm2.1Ley 		involves: 129X1/SvJ MGI:4421421


Genotype
MGI:4354613
hm1
Allelic
Composition		 Gzmatm1Ley/Gzmatm1Ley
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzmatm1Ley mutation (1 available); any Gzma mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor growth/size ( J:126114 )
• tumor burden in mice challenged with RMAS cells is increased compared to in similarly treated wild-type mice




Genotype
MGI:3526728
hm2
Allelic
Composition		 Gzmatm1Ley/Gzmatm1Ley
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzmatm1Ley mutation (1 available); any Gzma mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased cytotoxic T cell cytolysis ( J:49361 )
• a slight but significant decrease in cytotoxic activity towards allogenic targets is seen, however cytotoxic lymphocytes develop, activate and proliferate normally

hematopoietic system
decreased cytotoxic T cell cytolysis ( J:49361 )
• a slight but significant decrease in cytotoxic activity towards allogenic targets is seen, however cytotoxic lymphocytes develop, activate and proliferate normally




Genotype
MGI:4354615
cx3
Allelic
Composition		 Gzmatm1Ley/Gzmatm1Ley
Gzmbtm1Ley/Gzmbtm1Ley
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzmatm1Ley mutation (1 available); any Gzma mutation (34 available)
Gzmbtm1Ley mutation (7 available); any Gzmb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:126114 )
• mice challenged with RMAS or B16 tumors exhibit increased lethality compared with similarly treated wild-type mice




Genotype
MGI:4421421
cx4
Allelic
Composition		 Gzmatm1Ley/Gzmatm1Ley
Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzmatm1Ley mutation (1 available); any Gzma mutation (34 available)
Gzmbtm2.1Ley mutation (1 available); any Gzmb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:126114 )
• phenotype is stated to be similar to that of Gzmatm1Ley Gzmbtm1Ley double homozygotes, however no data is presented in J:126114




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory