Phenotypes associated with this allele

• Allele Symbol: Pbrm1^tm1Rtj
• Allele Name: targeted mutation 1, Robert Tjian
• Allele ID: MGI:3526660
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pbrm1^tm1Rtj/Pbrm1^tm1Rtj	Not Specified	MGI:3529460

Genotype
MGI:3529460

hm1

• Allelic Composition: Pbrm1^tm1Rtj/Pbrm1^tm1Rtj
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:95332 )

• homozygous mice die between E12.5 and E15.5

cardiovascular system

abnormal interventricular septum morphology ( J:95332 )

ventricular hypoplasia ( J:95332 )

• homozygous embryos had severe hypoplasia of the cardiac ventricular free walls

• tetraploid aggregation does not rescue the heart defects

embryo

abnormal trophoblast giant cell morphology ( J:95332 )

• homozygous embryos had abnormal placental morphology in which abnormal trophoblasts accumulated within labyrinth layer

abnormal spongiotrophoblast layer morphology ( J:95332 )

• thinner and less vascularized

abnormal placenta labyrinth morphology ( J:95332 )

• large clusters of packed trophoblasts replace the maternal and fetal blood space

liver/biliary system

small liver ( J:95332 )

• viable homozygous embryos at E13.5-14.5 had smaller liver than wild-type

respiratory system

small lung ( J:95332 )

• viable homozygous embryos at E13.5-14.5 had smaller lung than wild-type